Reactome | Phosphorylated TAK1 leaves activated TLR receptor complex

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Phosphorylated TAK1 leaves activated TLR receptor complex Show undefined attributes

authored	[InstanceEdit:937113] Shamovsky, V, 2010-08-25
category	dissociation
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:937065] Shamovsky, V, 2010-08-25
dbId	937075
displayName	Phosphorylated TAK1 leaves activated TLR receptor complex
edited	[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
eventOf	[Pathway:R-HSA-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - Homo sapiens
input	[Complex:R-HSA-936946] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:177899] Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR [LiteratureReference:169927] Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Phosphorylated TAK1 leaves activated TLR receptor complex
orthologousEvent	[Reaction:R-GGA-1008270] Activated TAK1 leaves endosome membrane - Gallus gallus [Reaction:R-GGA-937075] Phosphorylated TAK1 leaves activated TLR receptor complex - Gallus gallus [Reaction:R-SSC-937075] Phosphorylated TAK1 leaves activated TLR receptor complex - Sus scrofa [Reaction:R-BTA-937075] Phosphorylated TAK1 leaves activated TLR receptor complex - Bos taurus [Reaction:R-CFA-937075] Phosphorylated TAK1 leaves activated TLR receptor complex - Canis familiaris [Reaction:R-RNO-937075] Phosphorylated TAK1 leaves activated TLR receptor complex - Rattus norvegicus [Reaction:R-MMU-937075] Phosphorylated TAK1 leaves activated TLR receptor complex - Mus musculus
output	[Complex:R-HSA-847073] K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] [Complex:R-HSA-166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
precedingEvent	[Reaction:R-HSA-936951] Activation of TAK1 complex bound to activated TLR4 complex - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-937075
summation	[Summation:937054] Phosphorylated TAK1 complexed with TRAF6-TAB1-TAB2/TAB3 leav...
updateTrackers	[UpdateTracker:9780582] Update Tracker - [Reaction:937075] Phosphorylated TAK1 leaves activated TLR receptor complex - v62:[add_removeOutput] [UpdateTracker:9788696] Update Tracker - [Reaction:937075] Phosphorylated TAK1 leaves activated TLR receptor complex - v41:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9780582] Update Tracker - [Reaction:937075] Phosphorylated TAK1 leaves activated TLR receptor complex - v62:[add_removeOutput] [UpdateTracker:9788696] Update Tracker - [Reaction:937075] Phosphorylated TAK1 leaves activated TLR receptor complex - v41:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex

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