Reactome | TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]

Schema > Complex > Entries

TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] Show undefined attributes

compartment	[Compartment:74700] endosome membrane
componentOf	[Complex:R-HSA-2201339] TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Homo sapiens [Complex:R-HSA-2562577] activated TLR4:TRIF:RIP1:FADD [endosome membrane] - Homo sapiens [Complex:R-HSA-2562542] activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-2201338] TRAF3 binds TICAM1:activated TLR4 complex - Homo sapiens [Reaction:R-HSA-2559568] SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 - Homo sapiens [Reaction:R-HSA-168921] TRIF:activated TLR3/TLR4 complex recruits RIP1 - Homo sapiens [Reaction:R-HSA-936985] Activated TLR4:TICAM1 recruits TRAF6 - Homo sapiens
created	[InstanceEdit:166171] de Bono, B, 2005-08-19 15:44:58
dbId	166172
deleted	[Deleted:9910833] Deletion of instance: 2201340
displayName	TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
hasComponent	2 × [EntityWithAccessionedSequence:R-HSA-166170] TICAM1 [cytosol] [Complex:R-HSA-166163] TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:171907] endosome lumen
inferredTo	[Complex:R-MMU-166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Mus musculus [Complex:R-RNO-166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Rattus norvegicus [Complex:R-CFA-166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Canis familiaris [Complex:R-BTA-166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Bos taurus [Complex:R-SSC-166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Sus scrofa [Complex:R-DRE-166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Danio rerio [Complex:R-GGA-166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Gallus gallus
literatureReference	[LiteratureReference:2423800] Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling [LiteratureReference:165909] LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters
maxDepth	5
memberOf	[CandidateSet:R-HSA-2569052] TRIF:activated TLR4 [endosome membrane] - Homo sapiens
modified	[InstanceEdit:9013873] Shamovsky, Veronica, 2017-07-26
name	TICAM1:TRAM:TLR4:LY96:LPS:CD14 TRIF:TRAM:TLR4:LY96:LPS:CD14
producedByEvent	[Reaction:R-HSA-166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) - Homo sapiens [Reaction:R-HSA-937075] Phosphorylated TAK1 leaves activated TLR receptor complex - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-166172
updateTrackers	[UpdateTracker:9872135] Update Tracker - [Complex:166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v41:[add_removeCompartment, add_removeHasComponent, modifyName, removeSpecies, updateContainedComponent] [UpdateTracker:9897540] Update Tracker - [Complex:166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v62:[addName] [UpdateTracker:9873044] Update Tracker - [Complex:166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent] [UpdateTracker:9867591] Update Tracker - [Complex:166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v25:[updateContainedComponent] [UpdateTracker:9890150] Update Tracker - [Complex:166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v52:[modifyName, updateContainedComponent] [UpdateTracker:9871327] Update Tracker - [Complex:166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v39:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9872135] Update Tracker - [Complex:166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v41:[add_removeCompartment, add_removeHasComponent, modifyName, removeSpecies, updateContainedComponent] [UpdateTracker:9897540] Update Tracker - [Complex:166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v62:[addName] [UpdateTracker:9873044] Update Tracker - [Complex:166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent] [UpdateTracker:9867591] Update Tracker - [Complex:166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v25:[updateContainedComponent] [UpdateTracker:9890150] Update Tracker - [Complex:166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v52:[modifyName, updateContainedComponent] [UpdateTracker:9871327] Update Tracker - [Complex:166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v39:[updateContainedComponent]
(replacementInstances)	[Deleted:9910833] Deletion of instance: 2201340
(output)	[Reaction:R-HSA-937075] Phosphorylated TAK1 leaves activated TLR receptor complex [Reaction:R-HSA-166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1)
(input)	[Reaction:R-HSA-2201338] TRAF3 binds TICAM1:activated TLR4 complex [Reaction:R-HSA-2559568] SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 [Reaction:R-HSA-168921] TRIF:activated TLR3/TLR4 complex recruits RIP1 [Reaction:R-HSA-936985] Activated TLR4:TICAM1 recruits TRAF6
(hasComponent)	[Complex:R-HSA-2201339] TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Complex:R-HSA-2213008] K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Complex:R-HSA-2569054] RIP3:TICAM1:activated TLR4 [endosome membrane] [Complex:R-HSA-937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Complex:R-HSA-168912] RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Complex:R-HSA-2562577] activated TLR4:TRIF:RIP1:FADD [endosome membrane] [Complex:R-HSA-2562542] activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] [Complex:R-HSA-2559578] SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Complex:R-HSA-936976] TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Complex:R-HSA-936965] K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
(hasMember)	[CandidateSet:R-HSA-2569052] TRIF:activated TLR4 [endosome membrane]

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