Reactome | TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1)

Schema > Reaction > Entries

TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) Show undefined attributes

authored	[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:166176] de Bono, B, 2005-08-19 15:48:42
dbId	166175
displayName	TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1)
edited	[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
eventOf	[Pathway:R-HSA-166166] MyD88-independent TLR4 cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-2201338] TRAF3 binds TICAM1:activated TLR4 complex - Homo sapiens [Reaction:R-HSA-2559568] SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 - Homo sapiens [Reaction:R-HSA-168921] TRIF:activated TLR3/TLR4 complex recruits RIP1 - Homo sapiens [Reaction:R-HSA-936985] Activated TLR4:TICAM1 recruits TRAF6 - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-166170] TICAM1 [cytosol] [Complex:R-HSA-166163] TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:177881] Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway [LiteratureReference:165861] TRAM is specifically involved in the Toll-like receptor 4-mediated [LiteratureReference:165909] LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1)
orthologousEvent	[Reaction:R-GGA-166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) - Gallus gallus [Reaction:R-SSC-166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) - Sus scrofa [Reaction:R-CFA-166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) - Canis familiaris [Reaction:R-RNO-166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) - Rattus norvegicus [Reaction:R-MMU-166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) - Mus musculus
output	[Complex:R-HSA-166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17 [InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-166175
summation	[Summation:169810] TRIF (TICAM1) mediates the MyD88-independent pathway from TL...
updateTrackers	[UpdateTracker:9788592] Update Tracker - [Reaction:166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) - v41:[addLiteratureReference] [UpdateTracker:9787395] Update Tracker - [Reaction:166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) - v45:[modifyText] [UpdateTracker:9782882] Update Tracker - [Reaction:166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) - v58:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788592] Update Tracker - [Reaction:166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) - v41:[addLiteratureReference] [UpdateTracker:9787395] Update Tracker - [Reaction:166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) - v45:[modifyText] [UpdateTracker:9782882] Update Tracker - [Reaction:166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) - v58:[modifyText]
(hasEvent)	[Pathway:R-HSA-166166] MyD88-independent TLR4 cascade
(precedingEvent)	[Reaction:R-HSA-2201338] TRAF3 binds TICAM1:activated TLR4 complex [Reaction:R-HSA-2559568] SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 [Reaction:R-HSA-168921] TRIF:activated TLR3/TLR4 complex recruits RIP1 [Reaction:R-HSA-936985] Activated TLR4:TICAM1 recruits TRAF6

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