Reactome | Activated TLR4:TICAM1 recruits TRAF6

Schema > Reaction > Entries

Activated TLR4:TICAM1 recruits TRAF6 Show undefined attributes

category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10484739
displayName	Activated TLR4:TICAM1 recruits TRAF6
eventOf	[Pathway:R-SSC-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-SSC-936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex - Sus scrofa
inferredFrom	[Reaction:R-HSA-936985] Activated TLR4:TICAM1 recruits TRAF6 - Homo sapiens
input	[Complex:R-SSC-166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [EntityWithAccessionedSequence:R-SSC-166366] TRAF6 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated TLR4:TICAM1 recruits TRAF6
output	[Complex:R-SSC-936976] TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
precedingEvent	[Reaction:R-SSC-166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) - Sus scrofa
regulatedBy	[NegativeRegulation:10459586] Negative regulation by 'SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-936985
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex
(precedingEvent)	[BlackBoxEvent:R-SSC-936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex
(inferredTo)	[Reaction:R-HSA-936985] Activated TLR4:TICAM1 recruits TRAF6