Activated TLR4:TICAM1 recruits TRAF6

Stable Identifier
Reaction [binding]
Homo sapiens
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TRAF6 is recruited to the N-terminal domain of TICAM1 and this event is followed by auto polyubiquitination and oligomerization of TRAF6.

Literature References
PubMed ID Title Journal Year
20047764 Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway

Matsumoto, M, Hatakeyama, S, Oshiumi, H, Funami, K, Seya, T, Sasai, M, Tatematsu, M

Mol Immunol 2010
15814722 Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif

Offermann, MK, Kaiser, WJ

J Immunol 2005
11057907 Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

Deng, L, Pickart, C, Spencer, E, You, J, Wang, C, Slaughter, C, Braun, A, Chen, ZJ, Yang, L

Cell 2000
16306937 Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

Hsu, LC, Raz, E, Häcker, G, Karin, M, Kamps, MP, Mann, M, Kratchmarova, I, Redecke, V, Blagoev, B, Häcker, H, Wagner, H, Wang, GG

Nature 2006
9744859 Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death

Arch, RH, Gedrich, RW, Thompson, CB

Genes Dev 1998
This event is regulated