Reactome | O-linked glycosylation of mucins

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O-linked glycosylation of mucins Show undefined attributes

authored	[InstanceEdit:913626] Jassal, B, 2010-07-19
created	[InstanceEdit:913626] Jassal, B, 2010-07-19
dbId	913709
displayName	O-linked glycosylation of mucins
doi	10.3180/REACT_115606.1
edited	[InstanceEdit:913626] Jassal, B, 2010-07-19
eventOf	[Pathway:R-HSA-5173105] O-linked glycosylation - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:24451] protein O-linked glycosylation via N-acetyl-galactosamine
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - Homo sapiens [Reaction:R-HSA-1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) - Homo sapiens [Reaction:R-HSA-914012] GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins - Homo sapiens [Reaction:R-HSA-6786012] CHST4 transfers SO4(2-) from PAPS to Core 2 mucins - Homo sapiens [Reaction:R-HSA-5694487] A4GNT transfers GlcNAc to core 2 mucins - Homo sapiens [Reaction:R-HSA-914010] B3GNT6 transfers GlcNAc to Tn antigen - Homo sapiens [Reaction:R-HSA-914018] GCNT3 transfers GlcNAc to Core 3 mucin - Homo sapiens [BlackBoxEvent:R-HSA-914005] Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein - Homo sapiens [BlackBoxEvent:R-HSA-914008] Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein - Homo sapiens [Reaction:R-HSA-1964501] Addition of galactose to Core 6 glycoprotein - Homo sapiens [BlackBoxEvent:R-HSA-914017] Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein - Homo sapiens [BlackBoxEvent:R-HSA-914006] Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein - Homo sapiens [Pathway:R-HSA-977068] Termination of O-glycan biosynthesis - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-12-08
literatureReference	[LiteratureReference:994117] Mucin-type O-glycosylation and its potential use in drug and vaccine development [Book:913692] O-GalNAc Glycans
maxDepth	3
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	O-linked glycosylation of mucins
orthologousEvent	[Pathway:R-PFA-913709] O-linked glycosylation of mucins - Plasmodium falciparum [Pathway:R-DDI-913709] O-linked glycosylation of mucins - Dictyostelium discoideum [Pathway:R-CEL-913709] O-linked glycosylation of mucins - Caenorhabditis elegans [Pathway:R-DME-913709] O-linked glycosylation of mucins - Drosophila melanogaster [Pathway:R-GGA-913709] O-linked glycosylation of mucins - Gallus gallus [Pathway:R-XTR-913709] O-linked glycosylation of mucins - Xenopus tropicalis [Pathway:R-DRE-913709] O-linked glycosylation of mucins - Danio rerio [Pathway:R-SSC-913709] O-linked glycosylation of mucins - Sus scrofa [Pathway:R-BTA-913709] O-linked glycosylation of mucins - Bos taurus [Pathway:R-CFA-913709] O-linked glycosylation of mucins - Canis familiaris [Pathway:R-RNO-913709] O-linked glycosylation of mucins - Rattus norvegicus [Pathway:R-MMU-913709] O-linked glycosylation of mucins - Mus musculus
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1964508] Ferrer, A, 2011-11-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-913709
summation	[Summation:913658] Mucins are a family of high molecular weight, heavily glycos...
updateTrackers	[UpdateTracker:9787234] Update Tracker - [Pathway:913709] O-linked glycosylation of mucins - v46:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9786891] Update Tracker - [Pathway:913709] O-linked glycosylation of mucins - v47:[updateContainedRLE] [UpdateTracker:9783818] Update Tracker - [Pathway:913709] O-linked glycosylation of mucins - v55:[addHasEvent] [UpdateTracker:9783703] Update Tracker - [Pathway:913709] O-linked glycosylation of mucins - v56:[updateContainedRLE] [UpdateTracker:9775342] Update Tracker - [Pathway:913709] O-linked glycosylation of mucins - v79:[updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9784221] Update Tracker - [Pathway:913709] O-linked glycosylation of mucins - v54:[addHasEvent, updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9787234] Update Tracker - [Pathway:913709] O-linked glycosylation of mucins - v46:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9786891] Update Tracker - [Pathway:913709] O-linked glycosylation of mucins - v47:[updateContainedRLE]
[UpdateTracker:9783818] Update Tracker - [Pathway:913709] O-linked glycosylation of mucins - v55:[addHasEvent]
[UpdateTracker:9783703] Update Tracker - [Pathway:913709] O-linked glycosylation of mucins - v56:[updateContainedRLE]
[UpdateTracker:9775342] Update Tracker - [Pathway:913709] O-linked glycosylation of mucins - v79:[updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9784221] Update Tracker - [Pathway:913709] O-linked glycosylation of mucins - v54:[addHasEvent, updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-5173105] O-linked glycosylation

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