Reactome | GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins

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GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins Show undefined attributes

authored	[InstanceEdit:913626] Jassal, B, 2010-07-19
catalystActivity	[CatalystActivity:914007] beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity of GCNTs [Golgi membrane]
category	transition
compartment	[Compartment:17963] Golgi lumen [Compartment:20699] Golgi membrane
created	[InstanceEdit:914014] Jassal, B, 2010-07-21
crossReference	[DatabaseIdentifier:9942383] RHEA:56213 [DatabaseIdentifier:9942385] RHEA:56217
dbId	914012
displayName	GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins
edited	[InstanceEdit:913626] Jassal, B, 2010-07-19
eventOf	[Pathway:R-HSA-913709] O-linked glycosylation of mucins - Homo sapiens
followingEvent	[Reaction:R-HSA-6786012] CHST4 transfers SO4(2-) from PAPS to Core 2 mucins - Homo sapiens [Reaction:R-HSA-5694487] A4GNT transfers GlcNAc to core 2 mucins - Homo sapiens
input	[DefinedSet:R-HSA-1462240] Core 1 mucins [Golgi lumen] [SimpleEntity:R-ALL-914003] UDP-GlcNAc [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:977008] Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen [LiteratureReference:977025] Molecular cloning and expression of a novel beta-1, 6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches [LiteratureReference:977006] Control of O-glycan branch formation. Molecular cloning and characterization of a novel thymus-associated core 2 beta1, 6-n-acetylglucosaminyltransferase
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins Addition of GlcNAc to the T antigen forms a Core 2 glycoprotein
orthologousEvent	[Reaction:R-GGA-914012] GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins - Gallus gallus [Reaction:R-XTR-914012] GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins - Xenopus tropicalis [Reaction:R-DRE-914012] GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins - Danio rerio [Reaction:R-SSC-914012] GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins - Sus scrofa [Reaction:R-BTA-914012] GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins - Bos taurus [Reaction:R-CFA-914012] GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins - Canis familiaris [Reaction:R-RNO-914012] GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins - Rattus norvegicus [Reaction:R-MMU-914012] GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins - Mus musculus
output	[DefinedSet:R-HSA-1462066] Core 2 mucins [Golgi lumen] [SimpleEntity:R-ALL-425969] H+ [Golgi lumen] [SimpleEntity:R-ALL-205687] UDP [Golgi lumen]
precedingEvent	[Reaction:R-HSA-1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1964508] Ferrer, A, 2011-11-04 [InstanceEdit:9944933] D'Eustachio, Peter, 2025-04-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-914012
summation	[Summation:977009] The human gene GCNT encodes beta-1,6-N-acetylglucosaminyltra...
updateTrackers	[UpdateTracker:9953593] Update Tracker - [Reaction:914012] GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins - v93:[removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9953593] Update Tracker - [Reaction:914012] GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins - v93:[removeOutput]
(precedingEvent)	[Reaction:R-HSA-6786012] CHST4 transfers SO4(2-) from PAPS to Core 2 mucins [Reaction:R-HSA-5694487] A4GNT transfers GlcNAc to core 2 mucins
(hasEvent)	[Pathway:R-HSA-913709] O-linked glycosylation of mucins