Reactome | C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)

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C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) Show undefined attributes

authored	[InstanceEdit:913626] Jassal, B, 2010-07-19
catalystActivity	[CatalystActivity:1964519] N-acetylgalactosaminide beta-1,3-galactosyltransferase activity of C1GALT1:C1GALT1C1 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:1964511] Jassal, B, 2011-11-04
crossReference	[DatabaseIdentifier:9942377] RHEA:15622
dbId	1964505
diseaseReaction	[FailedReaction:R-HSA-6785524] Defective C1GALT1C1 does not bind C1GALT1 - Homo sapiens
displayName	C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)
edited	[InstanceEdit:913626] Jassal, B, 2010-07-19
eventOf	[Pathway:R-HSA-913709] O-linked glycosylation of mucins - Homo sapiens
followingEvent	[Reaction:R-HSA-981814] ST6GALNAC2 transfers sialic acid to Core 1 mucins - Homo sapiens [Reaction:R-HSA-981497] ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position - Homo sapiens [Reaction:R-HSA-914012] GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins - Homo sapiens
input	[DefinedSet:R-HSA-913659] Tn antigens [Golgi lumen] [SimpleEntity:R-ALL-735682] UDP-Gal [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6785505] New mutations in C1GALT1C1 in individuals with Tn positive phenotype [LiteratureReference:6785528] The Cosmc connection to the Tn antigen in cancer
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)
orthologousEvent	[Reaction:R-CEL-1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) - Caenorhabditis elegans [Reaction:R-DME-1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) - Drosophila melanogaster [Reaction:R-GGA-1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) - Gallus gallus [Reaction:R-XTR-1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) - Xenopus tropicalis [Reaction:R-DRE-1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) - Danio rerio [Reaction:R-SSC-1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) - Sus scrofa [Reaction:R-BTA-1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) - Bos taurus [Reaction:R-CFA-1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) - Canis familiaris [Reaction:R-RNO-1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) - Rattus norvegicus [Reaction:R-MMU-1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) - Mus musculus
output	[DefinedSet:R-HSA-1462240] Core 1 mucins [Golgi lumen] [SimpleEntity:R-ALL-425969] H+ [Golgi lumen] [SimpleEntity:R-ALL-205687] UDP [Golgi lumen]
precedingEvent	[Reaction:R-HSA-913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1964508] Ferrer, A, 2011-11-04 [InstanceEdit:9944933] D'Eustachio, Peter, 2025-04-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1964505
summation	[Summation:1964507] Glycoprotein N acetylgalactosamine 3 beta galactosyltransfer...
updateTrackers	[UpdateTracker:9953617] Update Tracker - [Reaction:1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) - v93:[removeOutput] [UpdateTracker:9783534] Update Tracker - [Reaction:1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) - v56:[add_removeLiteratureReference, modifyText] [UpdateTracker:9784145] Update Tracker - [Reaction:1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) - v54:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9953617] Update Tracker - [Reaction:1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) - v93:[removeOutput] [UpdateTracker:9783534] Update Tracker - [Reaction:1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) - v56:[add_removeLiteratureReference, modifyText] [UpdateTracker:9784145] Update Tracker - [Reaction:1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) - v54:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-6785524] Defective C1GALT1C1 does not bind C1GALT1
(hasEvent)	[Pathway:R-HSA-913709] O-linked glycosylation of mucins
(precedingEvent)	[Reaction:R-HSA-981814] ST6GALNAC2 transfers sialic acid to Core 1 mucins [Reaction:R-HSA-981497] ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position [Reaction:R-HSA-914012] GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins

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