Reactome | GALNTs transfer GalNAc to Mucins to form Tn antigens

Schema > Reaction > Entries

GALNTs transfer GalNAc to Mucins to form Tn antigens Show undefined attributes

authored	[InstanceEdit:913626] Jassal, B, 2010-07-19
catalystActivity	[CatalystActivity:913697] polypeptide N-acetylgalactosaminyltransferase activity of GALNTs [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:913626] Jassal, B, 2010-07-19
crossReference	[DatabaseIdentifier:9942380] RHEA:23957 [DatabaseIdentifier:9942378] RHEA:52425
dbId	913675
diseaseReaction	[FailedReaction:R-HSA-5096532] Defective GALNT12 does not transfer GalNAc to mucins - Homo sapiens [FailedReaction:R-HSA-5096537] Defective GALNT3 does not transfer GalNAc to mucins - Homo sapiens
displayName	GALNTs transfer GalNAc to Mucins to form Tn antigens
edited	[InstanceEdit:913626] Jassal, B, 2010-07-19
eventOf	[Pathway:R-HSA-913709] O-linked glycosylation of mucins - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-914006] Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein - Homo sapiens [BlackBoxEvent:R-HSA-914005] Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein - Homo sapiens [Reaction:R-HSA-914010] B3GNT6 transfers GlcNAc to Tn antigen - Homo sapiens [BlackBoxEvent:R-HSA-914017] Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein - Homo sapiens [BlackBoxEvent:R-HSA-914008] Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein - Homo sapiens [Reaction:R-HSA-977071] ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens - Homo sapiens [Reaction:R-HSA-1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) - Homo sapiens
input	[DefinedSet:R-HSA-913666] Mucins [Golgi lumen] [SimpleEntity:R-ALL-9942384] UDP-GalNAc [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:976842] Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3 [LiteratureReference:977014] Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus [LiteratureReference:8849565] Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	GALNTs transfer GalNAc to Mucins to form Tn antigens Addition of GalNAc to mucins to form the Tn antigen
orthologousEvent	[Reaction:R-CEL-913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - Caenorhabditis elegans [Reaction:R-DME-913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - Drosophila melanogaster [Reaction:R-GGA-913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - Gallus gallus [Reaction:R-XTR-913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - Xenopus tropicalis [Reaction:R-DRE-913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - Danio rerio [Reaction:R-SSC-913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - Sus scrofa [Reaction:R-BTA-913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - Bos taurus [Reaction:R-CFA-913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - Canis familiaris [Reaction:R-RNO-913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - Rattus norvegicus [Reaction:R-MMU-913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - Mus musculus
output	[SimpleEntity:R-ALL-425969] H+ [Golgi lumen] [DefinedSet:R-HSA-913659] Tn antigens [Golgi lumen] [SimpleEntity:R-ALL-205687] UDP [Golgi lumen]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1964508] Ferrer, A, 2011-11-04 [InstanceEdit:9944933] D'Eustachio, Peter, 2025-04-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-913675
summation	[Summation:976826] The family of UDP GalNAc:polypeptide N acetylgalactosaminylt...
updateTrackers	[UpdateTracker:9786842] Update Tracker - [Reaction:913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - v47:[modifyText] [UpdateTracker:9953576] Update Tracker - [Reaction:913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - v93:[add_removeInput, removeOutput] [UpdateTracker:9783512] Update Tracker - [Reaction:913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - v56:[add_removeLiteratureReference, modifyText] [UpdateTracker:9775469] Update Tracker - [Reaction:913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - v79:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9786842] Update Tracker - [Reaction:913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - v47:[modifyText] [UpdateTracker:9953576] Update Tracker - [Reaction:913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - v93:[add_removeInput, removeOutput] [UpdateTracker:9783512] Update Tracker - [Reaction:913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - v56:[add_removeLiteratureReference, modifyText] [UpdateTracker:9775469] Update Tracker - [Reaction:913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - v79:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-5096532] Defective GALNT12 does not transfer GalNAc to mucins [FailedReaction:R-HSA-5096537] Defective GALNT3 does not transfer GalNAc to mucins
(precedingEvent)	[BlackBoxEvent:R-HSA-914006] Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein [BlackBoxEvent:R-HSA-914005] Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein [Reaction:R-HSA-914010] B3GNT6 transfers GlcNAc to Tn antigen [BlackBoxEvent:R-HSA-914017] Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein [BlackBoxEvent:R-HSA-914008] Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein [Reaction:R-HSA-977071] ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens [Reaction:R-HSA-1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)
(hasEvent)	[Pathway:R-HSA-913709] O-linked glycosylation of mucins

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