Reactome | O-linked glycosylation of mucins

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O-linked glycosylation of mucins Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10444824
displayName	O-linked glycosylation of mucins
eventOf	[Pathway:R-BTA-5173105] O-linked glycosylation - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:24451] protein O-linked glycosylation via N-acetyl-galactosamine
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-BTA-913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - Bos taurus [Reaction:R-BTA-1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) - Bos taurus [Reaction:R-BTA-914012] GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins - Bos taurus [Reaction:R-BTA-6786012] CHST4 transfers SO4(2-) from PAPS to Core 2 mucins - Bos taurus [Reaction:R-BTA-5694487] A4GNT transfers GlcNAc to core 2 mucins - Bos taurus [Reaction:R-BTA-914010] B3GNT6 transfers GlcNAc to Tn antigen - Bos taurus [Reaction:R-BTA-914018] GCNT3 transfers GlcNAc to Core 3 mucin - Bos taurus [BlackBoxEvent:R-BTA-914005] Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein - Bos taurus [BlackBoxEvent:R-BTA-914008] Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein - Bos taurus [Reaction:R-BTA-1964501] Addition of galactose to Core 6 glycoprotein - Bos taurus [BlackBoxEvent:R-BTA-914017] Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein - Bos taurus [BlackBoxEvent:R-BTA-914006] Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein - Bos taurus [Pathway:R-BTA-977068] Termination of O-glycan biosynthesis - Bos taurus
inferredFrom	[Pathway:R-HSA-913709] O-linked glycosylation of mucins - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	O-linked glycosylation of mucins
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-913709
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5173105] O-linked glycosylation
(inferredTo)	[Pathway:R-HSA-913709] O-linked glycosylation of mucins

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