Reactome | NICD3 binds RBPJ and MAML in the nucleus

Schema > Reaction > Entries

NICD3 binds RBPJ and MAML in the nucleus Show undefined attributes

authored	[InstanceEdit:9021699] Orlic-Milacic, Marija, 2017-09-20
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9013639] Orlic-Milacic, Marija, 2017-07-25
dbId	9013631
displayName	NICD3 binds RBPJ and MAML in the nucleus
edited	[InstanceEdit:9015332] Orlic-Milacic, Marija, 2017-08-09 [InstanceEdit:9027527] Orlic-Milacic, Marija, 2017-11-02
eventOf	[Pathway:R-HSA-9013508] NOTCH3 Intracellular Domain Regulates Transcription - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9017398] NOTCH3 coactivator complex binds HEYL gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9014129] HEY1 gene expression is positively regulated by NOTCH3 and STAT1 - Homo sapiens [Reaction:R-HSA-9013652] NOTCH3 coactivator complex binds HES1 gene promoter - Homo sapiens [Reaction:R-HSA-9016916] NOTCH3 coactivator complex binds the PTCRA gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9014141] HEY2 gene expression is positively regulated by NOTCH3 - Homo sapiens [Reaction:R-HSA-9021406] NOTCH3 coactivator complex binds PBX1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9013568] HES5 gene expression is stimulated by NOTCH3 - Homo sapiens [BlackBoxEvent:R-HSA-9016751] FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 - Homo sapiens [Reaction:R-HSA-9021325] NOTCH3 coactivator complex and STAT1 bind HES1 gene promoter - Homo sapiens [Reaction:R-HSA-9018542] NOTCH3 coactivator complex binds DLGAP5 gene promoter - Homo sapiens [Reaction:R-HSA-9021451] NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter - Homo sapiens [Reaction:R-HSA-9021480] NOTCH3 coactivator complex binds WWC1 (Kibra) gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-1912415] NOTCH3 gene transcription - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:20142] positive regulation of transcription of Notch receptor target
inferredFrom	[Reaction:R-NUL-9013647] NICD3 binds RBPJ and MAML in the nucleus - Homo sapiens
input	[CandidateSet:R-HSA-212357] MAML [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-157928] NICD3 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3008668] RBPJ [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NICD3 binds RBPJ and MAML in the nucleus
output	[Complex:R-HSA-2248837] NOTCH3 coactivator complex [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-157937] NICD3 traffics to the nucleus - Homo sapiens
releaseDate	2017-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9027525] Haw, Robin, 2017-10-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9013631
summation	[Summation:9013634] In the nucleus, NICD3 forms a complex with RBPJ (CBF1, CSL) ...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9017398] NOTCH3 coactivator complex binds HEYL gene promoter [BlackBoxEvent:R-HSA-9014129] HEY1 gene expression is positively regulated by NOTCH3 and STAT1 [Reaction:R-HSA-9013652] NOTCH3 coactivator complex binds HES1 gene promoter [Reaction:R-HSA-9016916] NOTCH3 coactivator complex binds the PTCRA gene promoter [BlackBoxEvent:R-HSA-9014141] HEY2 gene expression is positively regulated by NOTCH3 [Reaction:R-HSA-9021406] NOTCH3 coactivator complex binds PBX1 gene promoter [BlackBoxEvent:R-HSA-9013568] HES5 gene expression is stimulated by NOTCH3 [BlackBoxEvent:R-HSA-9016751] FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 [Reaction:R-HSA-9021325] NOTCH3 coactivator complex and STAT1 bind HES1 gene promoter [Reaction:R-HSA-9018542] NOTCH3 coactivator complex binds DLGAP5 gene promoter [Reaction:R-HSA-9021451] NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter [Reaction:R-HSA-9021480] NOTCH3 coactivator complex binds WWC1 (Kibra) gene promoter [BlackBoxEvent:R-HSA-1912415] NOTCH3 gene transcription
(hasEvent)	[Pathway:R-HSA-9013508] NOTCH3 Intracellular Domain Regulates Transcription
(inferredTo)	[Reaction:R-NUL-9013647] NICD3 binds RBPJ and MAML in the nucleus

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