Reactome | HEY1 gene expression is positively regulated by NOTCH3 and STAT1

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HEY1 gene expression is positively regulated by NOTCH3 and STAT1 Show undefined attributes

authored	[InstanceEdit:9021699] Orlic-Milacic, Marija, 2017-09-20
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9014130] Orlic-Milacic, Marija, 2017-07-26
dbId	9014129
displayName	HEY1 gene expression is positively regulated by NOTCH3 and STAT1
edited	[InstanceEdit:9027527] Orlic-Milacic, Marija, 2017-11-02
eventOf	[Pathway:R-HSA-9013508] NOTCH3 Intracellular Domain Regulates Transcription - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:20142] positive regulation of transcription of Notch receptor target
inferredFrom	[BlackBoxEvent:R-NUL-9014136] Hey1 gene expression is positively regulated by Notch3 - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-4396358] HEY1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9021321] Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HEY1 gene expression is positively regulated by NOTCH3 and STAT1
output	[EntityWithAccessionedSequence:R-HSA-1606744] HEY1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9013631] NICD3 binds RBPJ and MAML in the nucleus - Homo sapiens [Reaction:R-HSA-9021334] STAT1 binds HEY1 gene promoter - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-9014131] Positive regulation by 'NOTCH3 coactivator complex [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-9021341] Positive gene expression regulation by 'p-Y701-STAT1 dimer:HEY1 gene [nucleoplasm]'
regulationReference	[RegulationReference:9642066] Positive gene expression regulation by 'p-Y701-STAT1 dimer:HEY1 gene [nucleoplasm]' Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways
releaseDate	2017-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9027525] Haw, Robin, 2017-10-30
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9014129
summation	[Summation:9014128] Based on a study involving mouse and rat proteins and DNA, N...

Referrals

(hasEvent)	[Pathway:R-HSA-9013508] NOTCH3 Intracellular Domain Regulates Transcription
(inferredTo)	[BlackBoxEvent:R-NUL-9014136] Hey1 gene expression is positively regulated by Notch3

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