Reactome | NOTCH3 coactivator complex [nucleoplasm]

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NOTCH3 coactivator complex [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-9017405] NOTCH3 coactivator complex:HEYL gene [nucleoplasm] - Homo sapiens
consumedByEvent	[BlackBoxEvent:R-HSA-9017398] NOTCH3 coactivator complex binds HEYL gene promoter - Homo sapiens [Reaction:R-HSA-9013652] NOTCH3 coactivator complex binds HES1 gene promoter - Homo sapiens [Reaction:R-HSA-9016916] NOTCH3 coactivator complex binds the PTCRA gene promoter - Homo sapiens [Reaction:R-HSA-9021406] NOTCH3 coactivator complex binds PBX1 gene promoter - Homo sapiens [Reaction:R-HSA-9021325] NOTCH3 coactivator complex and STAT1 bind HES1 gene promoter - Homo sapiens [Reaction:R-HSA-9018542] NOTCH3 coactivator complex binds DLGAP5 gene promoter - Homo sapiens [Reaction:R-HSA-9021480] NOTCH3 coactivator complex binds WWC1 (Kibra) gene promoter - Homo sapiens
created	[InstanceEdit:2248836] Orlic-Milacic, M, 2012-05-14
dbId	2248837
displayName	NOTCH3 coactivator complex [nucleoplasm]
hasComponent	[CandidateSet:R-HSA-212357] MAML [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-157928] NICD3 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3008668] RBPJ [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-2248837] NOTCH3 coactivator complex [nucleoplasm] - Mus musculus [Complex:R-RNO-2248837] NOTCH3 coactivator complex [nucleoplasm] - Rattus norvegicus [Complex:R-XTR-2248837] NOTCH3 coactivator complex [nucleoplasm] - Xenopus tropicalis [Complex:R-GGA-2248837] NOTCH3 coactivator complex [nucleoplasm] - Gallus gallus
isChimeric	false
maxDepth	3
memberOf	[DefinedSet:R-HSA-9016789] NOTCH1,NOTCH3 coactivator complexes [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:9013657] Orlic-Milacic, Marija, 2017-07-25
name	NOTCH3 coactivator complex
positivelyRegulates	[PositiveRegulation:R-HSA-9014131] Positive regulation by 'NOTCH3 coactivator complex [nucleoplasm]' [PositiveRegulation:R-HSA-9014151] Positive regulation by 'NOTCH3 coactivator complex [nucleoplasm]' [PositiveRegulation:R-HSA-9013732] Positive regulation by 'NOTCH3 coactivator complex [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-2248835] Positive gene expression regulation by 'NOTCH3 coactivator complex [nucleoplasm]'
producedByEvent	[Reaction:R-HSA-9013631] NICD3 binds RBPJ and MAML in the nucleus - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-2248837
updateTrackers	[UpdateTracker:9897811] Update Tracker - [Complex:2248837] NOTCH3 coactivator complex [nucleoplasm] - v62:[modifyName] [UpdateTracker:9877989] Update Tracker - [Complex:2248837] NOTCH3 coactivator complex [nucleoplasm] - v44:[add_removeHasComponent]

Referrals

(updatedInstance)	[UpdateTracker:9897811] Update Tracker - [Complex:2248837] NOTCH3 coactivator complex [nucleoplasm] - v62:[modifyName] [UpdateTracker:9877989] Update Tracker - [Complex:2248837] NOTCH3 coactivator complex [nucleoplasm] - v44:[add_removeHasComponent]
(input)	[BlackBoxEvent:R-HSA-9017398] NOTCH3 coactivator complex binds HEYL gene promoter [Reaction:R-HSA-9013652] NOTCH3 coactivator complex binds HES1 gene promoter [Reaction:R-HSA-9016916] NOTCH3 coactivator complex binds the PTCRA gene promoter [Reaction:R-HSA-9021406] NOTCH3 coactivator complex binds PBX1 gene promoter [Reaction:R-HSA-9021325] NOTCH3 coactivator complex and STAT1 bind HES1 gene promoter [Reaction:R-HSA-9018542] NOTCH3 coactivator complex binds DLGAP5 gene promoter [Reaction:R-HSA-9021480] NOTCH3 coactivator complex binds WWC1 (Kibra) gene promoter
(hasComponent)	[Complex:R-HSA-9017405] NOTCH3 coactivator complex:HEYL gene [nucleoplasm] [Complex:R-HSA-9013653] NOTCH3 coactivator complex:HES1 gene [nucleoplasm] [Complex:R-HSA-9016914] NOTCH3 coactivator complex:PTCRA gene [nucleoplasm] [Complex:R-HSA-9021411] NOTCH3 coactivator complex:PBX1 gene [nucleoplasm] [Complex:R-HSA-9021313] NOTCH3 coactivator complex:p-Y701-STAT1 dimer:HES1 gene [nucleoplasm] [Complex:R-HSA-9018547] NOTCH3 coactivator complex:DLGAP5 gene [nucleoplasm] [Complex:R-HSA-9021490] NOTCH3 coactivator complex:WWC1 gene [nucleoplasm]
(regulator)	[PositiveRegulation:R-HSA-9014131] Positive regulation by 'NOTCH3 coactivator complex [nucleoplasm]' [PositiveRegulation:R-HSA-9014151] Positive regulation by 'NOTCH3 coactivator complex [nucleoplasm]' [PositiveRegulation:R-HSA-9013732] Positive regulation by 'NOTCH3 coactivator complex [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-2248835] Positive gene expression regulation by 'NOTCH3 coactivator complex [nucleoplasm]'
(activeUnit)	[PositiveGeneExpressionRegulation:R-HSA-9013682] Positive gene expression regulation by 'NOTCH3 coactivator complex:HES1 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-9021329] Positive gene expression regulation by 'NOTCH3 coactivator complex:p-Y701-STAT1 dimer:HES1 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-9016899] Positive gene expression regulation by 'NOTCH3 coactivator complex:PTCRA gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-9021487] Positive gene expression regulation by 'NOTCH3 coactivator complex:WWC1 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-9021407] Positive gene expression regulation by 'NOTCH3 coactivator complex:PBX1 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-9018548] Positive gene expression regulation by 'NOTCH3 coactivator complex:DLGAP5 gene [nucleoplasm]'
(hasMember)	[DefinedSet:R-HSA-9016789] NOTCH1,NOTCH3 coactivator complexes [nucleoplasm]
(output)	[Reaction:R-HSA-9013631] NICD3 binds RBPJ and MAML in the nucleus

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