Reactome | NOTCH3 Intracellular Domain Regulates Transcription

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NOTCH3 Intracellular Domain Regulates Transcription Show undefined attributes

authored	[InstanceEdit:9021699] Orlic-Milacic, Marija, 2017-09-20
created	[InstanceEdit:9013509] Orlic-Milacic, Marija, 2017-07-25
dbId	9013508
displayName	NOTCH3 Intracellular Domain Regulates Transcription
edited	[InstanceEdit:9027527] Orlic-Milacic, Marija, 2017-11-02
eventOf	[Pathway:R-HSA-9012852] Signaling by NOTCH3 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:20142] positive regulation of transcription of Notch receptor target
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9013631] NICD3 binds RBPJ and MAML in the nucleus - Homo sapiens [Reaction:R-HSA-9013652] NOTCH3 coactivator complex binds HES1 gene promoter - Homo sapiens [Reaction:R-HSA-9021325] NOTCH3 coactivator complex and STAT1 bind HES1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9013567] HES1 gene expression is stimulated by NOTCH3 and STAT1 - Homo sapiens [BlackBoxEvent:R-HSA-9017398] NOTCH3 coactivator complex binds HEYL gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9013488] HEYL gene expression is stimulated by NOTCH3 - Homo sapiens [BlackBoxEvent:R-HSA-9013568] HES5 gene expression is stimulated by NOTCH3 - Homo sapiens [Reaction:R-HSA-9021334] STAT1 binds HEY1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9014129] HEY1 gene expression is positively regulated by NOTCH3 and STAT1 - Homo sapiens [BlackBoxEvent:R-HSA-9014141] HEY2 gene expression is positively regulated by NOTCH3 - Homo sapiens [BlackBoxEvent:R-HSA-9016751] FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 - Homo sapiens [Reaction:R-HSA-9016916] NOTCH3 coactivator complex binds the PTCRA gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9017120] IK1 binds the PTCRA gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9016861] PTCRA gene expression is stimulated by NOTCH3 and inhibited by IK1 - Homo sapiens [Reaction:R-HSA-9018542] NOTCH3 coactivator complex binds DLGAP5 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9018538] DLGAP5 gene transcription is stimulated by NOTCH3 - Homo sapiens [Reaction:R-HSA-9021406] NOTCH3 coactivator complex binds PBX1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9021412] PBX1 gene expression is stimulated by NOTCH3 - Homo sapiens [Reaction:R-HSA-9021451] NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9021450] PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes - Homo sapiens [Reaction:R-HSA-9021480] NOTCH3 coactivator complex binds WWC1 (Kibra) gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9021478] WWC1 (Kibra) gene expression is stimulated by NOTCH3 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9015723] Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma [LiteratureReference:9016812] Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability [LiteratureReference:9016821] Cross talk among Notch3, pre-TCR, and Tal1 in T-cell development and leukemogenesis [LiteratureReference:9016847] Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia [LiteratureReference:9017728] Notch and Ikaros: not only converging players in T cell leukemia [LiteratureReference:9016860] Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing [LiteratureReference:9016745] Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells [LiteratureReference:9018540] Defining NOTCH3 target genes in ovarian cancer [LiteratureReference:9016756] Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1 [LiteratureReference:9013630] Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling [LiteratureReference:9021408] Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer [LiteratureReference:2197547] Functional diversity among Notch1, Notch2, and Notch3 receptors [LiteratureReference:9021453] PlexinD1 Is a Novel Transcriptional Target and Effector of Notch Signaling in Cancer Cells [LiteratureReference:9014127] Coordinate Notch3-hairy-related transcription factor pathway regulation in response to arterial injury. Mediator role of platelet-derived growth factor and ERK [LiteratureReference:9021483] Notch3 inhibits epithelial-mesenchymal transition by activating Kibra-mediated Hippo/YAP signaling in breast cancer epithelial cells
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NOTCH3 Intracellular Domain Regulates Transcription
releaseDate	2017-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9027525] Haw, Robin, 2017-10-30
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9013508
summation	[Summation:9015719] In the nucleus, NICD3 forms a complex with RBPJ (CBF1, CSL) ...

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[Pathway:R-HSA-9012852] Signaling by NOTCH3

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