Reactome | NOTCH3 coactivator complex binds WWC1 (Kibra) gene promoter

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NOTCH3 coactivator complex binds WWC1 (Kibra) gene promoter Show undefined attributes

authored	[InstanceEdit:9021699] Orlic-Milacic, Marija, 2017-09-20
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9021479] Orlic-Milacic, Marija, 2017-09-18
dbId	9021480
displayName	NOTCH3 coactivator complex binds WWC1 (Kibra) gene promoter
edited	[InstanceEdit:9027527] Orlic-Milacic, Marija, 2017-11-02
eventOf	[Pathway:R-HSA-9013508] NOTCH3 Intracellular Domain Regulates Transcription - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9021478] WWC1 (Kibra) gene expression is stimulated by NOTCH3 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:20142] positive regulation of transcription of Notch receptor target
input	[Complex:R-HSA-2248837] NOTCH3 coactivator complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9021489] WWC1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9021483] Notch3 inhibits epithelial-mesenchymal transition by activating Kibra-mediated Hippo/YAP signaling in breast cancer epithelial cells
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NOTCH3 coactivator complex binds WWC1 (Kibra) gene promoter
output	[Complex:R-HSA-9021490] NOTCH3 coactivator complex:WWC1 gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9013631] NICD3 binds RBPJ and MAML in the nucleus - Homo sapiens
releaseDate	2017-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9027525] Haw, Robin, 2017-10-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9021480
summation	[Summation:9021497] The WWC1 (Kibra) gene promoter region contains two RBPJ-bind...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9021478] WWC1 (Kibra) gene expression is stimulated by NOTCH3
(hasEvent)	[Pathway:R-HSA-9013508] NOTCH3 Intracellular Domain Regulates Transcription

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