Reactome | Binding of AP1 transcriptional activator complexes to CCND1 promoter

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Binding of AP1 transcriptional activator complexes to CCND1 promoter Show undefined attributes

authored	[InstanceEdit:9024061] Rothfels, Karen, 2017-09-29
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9009372] Rothfels, Karen, 2017-06-16
dbId	9009371
displayName	Binding of AP1 transcriptional activator complexes to CCND1 promoter
edited	[InstanceEdit:9028899] Rothfels, Karen, 2017-11-13
eventOf	[Pathway:R-HSA-9018519] Estrogen-dependent gene expression - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9009378] Estrogen-responsive CCND1 gene expression - Homo sapiens
input	[Complex:R-HSA-9009057] CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-381325] EP300 [nucleoplasm] [Complex:R-HSA-9009370] ESTG:ESR1 dimer:ATF2:JUN [nucleoplasm] [Complex:R-HSA-9009373] ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-83836] POU2F1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9009347] The elements of human cyclin D1 promoter and regulation involved [LiteratureReference:9009352] Transcriptional regulation of the cyclin D1 gene at a glance [LiteratureReference:9009325] Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions [LiteratureReference:9009005] Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter [LiteratureReference:9009340] The AP-1 transcription factor regulates breast cancer cell growth via cyclins and E2F factors [LiteratureReference:9009368] Estrogen induction of the cyclin D1 promoter: involvement of a cAMP response-like element [LiteratureReference:9009355] Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements [LiteratureReference:9008977] A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer [LiteratureReference:9009039] Pioneer transcription factors: establishing competence for gene expression [LiteratureReference:9009047] Steroid Receptors Reprogram FoxA1 Occupancy through Dynamic Chromatin Transitions
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Binding of AP1 transcriptional activator complexes to CCND1 promoter
orthologousEvent	[Reaction:R-GGA-9009371] Binding of AP1 transcriptional activator complexes to CCND1 promoter - Gallus gallus [Reaction:R-SSC-9009371] Binding of AP1 transcriptional activator complexes to CCND1 promoter - Sus scrofa [Reaction:R-BTA-9009371] Binding of AP1 transcriptional activator complexes to CCND1 promoter - Bos taurus [Reaction:R-CFA-9009371] Binding of AP1 transcriptional activator complexes to CCND1 promoter - Canis familiaris [Reaction:R-RNO-9009371] Binding of AP1 transcriptional activator complexes to CCND1 promoter - Rattus norvegicus
output	[Complex:R-HSA-9009369] CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOS [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9009065] FOXA1 and GATA3 bind to CCND1 promoter - Homo sapiens [Reaction:R-HSA-8939201] ESR dimerizes - Homo sapiens
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9038169] Magnani, Luca, 2018-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9009371
summation	[Summation:9009655] Although there is not a classical estrogen response element ...

Referrals

(hasEvent)	[Pathway:R-HSA-9018519] Estrogen-dependent gene expression
(precedingEvent)	[BlackBoxEvent:R-HSA-9009378] Estrogen-responsive CCND1 gene expression

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