Reactome | Binding of AP1 transcriptional activator complexes to CCND1 promoter

Binding of AP1 transcriptional activator complexes to CCND1 promoter

Stable Identifier

R-HSA-9009371

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Binding of AP1 transcriptional activator complexes to CCND1 promoter

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Although there is not a classical estrogen response element (ERE) in the proximal CCND1 promoter, estrogen-responsive transcription is mediated through recruitment of hormone-bound ESR1 by other DNA-binding proteins (reviewed in Guo et al, 2011; Klein and Assoian, 2008). A heterodimer of JUN:FOS binds to an estrogen-responsive G1 element (ERGE) between nucleotides -948 and -925 and is responsible for recruitment of ESR1 and estrogen to this site. OCT1 may facilitate this binding by displacing a YY1:HDAC1 repressive complex that occupies an adjacent site in unstimulated cells (Albanese et al, 1995; Cicatiello et al, 2004; Shen et al, 2007). Binding of ATF2:JUN heterodimers to a cyclic AMP response element (CRE) located 52 nucleotides upstream of the transcriptional start site may also contribute to estrogen-responsive signaling (Sabbah et al, 1999; Castro-Rivera at al, 2001). An ERE has been identified in an enhancer element downstream of the CCND1 gene (enh2). This enhancer binds to FOXA1, and also mediates recruitment of the histone acetyltransferase p300 to the CCND1 promoter (Eeckhoute et al, 2006).
Although FOXA1 and GATA3 were initially characterized as 'pioneer' transcription factors that bind to closed chromatin conformations and prime recruitment of sequence-specific DNA binding factors, more recent studies have questioned the order of recruitment of the estrogen receptors, FOXA1 and GATA3 to estrogen-responsive targets (Swinstead et al, 2016).

Literature References

PubMed ID	Title	Journal	Year
27062924	Steroid Receptors Reprogram FoxA1 Occupancy through Dynamic Chromatin Transitions Mazza, D, Swinstead, EE, Ball, D, Paakinaho, V, Miranda, TB, Grimm, JB, Karpova, TS, Hager, GL, Baek, S, Goldstein, I, Morisaki, T, Presman, DM, Grøntved, L, Lavis, LD, Hawkins, M	Cell	2016
22704330	The elements of human cyclin D1 promoter and regulation involved Yang, F, Hao, XH, Jiang, XL, Tan, FF, Shang, LM, Guo, ZY, Pei, X	Clin Epigenetics	2011
16980581	A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer Brown, M, Geistlinger, TR, Torres-Arzayus, MI, Eeckhoute, J, Carroll, JS	Genes Dev.	2006
22056668	Pioneer transcription factors: establishing competence for gene expression Zaret, KS, Carroll, JS	Genes Dev.	2011
17637753	The AP-1 transcription factor regulates breast cancer cell growth via cyclins and E2F factors Uray, IP, Li, Y, Strecker, TE, Brown, PH, Kim, HT, Krisko, TI, Shen, Q	Oncogene	2008
15282324	Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter Caristi, S, Perillo, B, Borgo, R, Addeo, R, Altucci, L, Scafoglio, C, Caporali, S, Cancemi, M, Teti, D, Sasso, A, Cicatiello, L, Weisz, A, Petrizzi, VB, Bresciani, F	Mol. Cell. Biol.	2004
7559524	Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions Albanese, C, Arnold, A, Pestell, RG, Vu, D, Johnson, J, Eklund, N, Watanabe, G	J. Biol. Chem.	1995
11410592	Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements Castro-Rivera, E, Samudio, I, Safe, S	J. Biol. Chem.	2001
10500157	Estrogen induction of the cyclin D1 promoter: involvement of a cAMP response-like element Courilleau, D, Sabbah, M, Redeuilh, G, Mester, J	Proc. Natl. Acad. Sci. U.S.A.	1999
19020303	Transcriptional regulation of the cyclin D1 gene at a glance Klein, EA, Assoian, RK	J. Cell. Sci.	2008