Reactome | FOXA1 and GATA3 bind to CCND1 promoter

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FOXA1 and GATA3 bind to CCND1 promoter Show undefined attributes

authored	[InstanceEdit:9024061] Rothfels, Karen, 2017-09-29
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9009066] Rothfels, Karen, 2017-06-14
dbId	9009065
displayName	FOXA1 and GATA3 bind to CCND1 promoter
edited	[InstanceEdit:9028899] Rothfels, Karen, 2017-11-13
eventOf	[Pathway:R-HSA-9018519] Estrogen-dependent gene expression - Homo sapiens
followingEvent	[Reaction:R-HSA-9009371] Binding of AP1 transcriptional activator complexes to CCND1 promoter - Homo sapiens
input	[Complex:R-HSA-9009060] CCND1 gene:H3K4me2 nucleosome:YY1:HDAC1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-453074] FOXA1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-996768] GATA3 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9008996] Downstream targets of growth factor and oestrogen signalling and endocrine resistance: the potential roles of c-Myc, cyclin D1 and cyclin E [LiteratureReference:9009005] Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter [LiteratureReference:9008985] Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1 [LiteratureReference:9009027] From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response [LiteratureReference:9008977] A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer [LiteratureReference:9009018] FOXA1 is a key determinant of estrogen receptor function and endocrine response [LiteratureReference:9008982] Cellular reprogramming by the conjoint action of ER?, FOXA1, and GATA3 to a ligand-inducible growth state [LiteratureReference:9009047] Steroid Receptors Reprogram FoxA1 Occupancy through Dynamic Chromatin Transitions [LiteratureReference:9011791] GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility [LiteratureReference:9009039] Pioneer transcription factors: establishing competence for gene expression [LiteratureReference:9009020] FOXA1: master of steroid receptor function in cancer [LiteratureReference:9008989] Cooperating transcription factors mediate the function of estrogen receptor [LiteratureReference:9009035] Meta-analysis of human cancer microarrays reveals GATA3 is integral to the estrogen receptor alpha pathway [LiteratureReference:9009024] FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	FOXA1 and GATA3 bind to CCND1 promoter
orthologousEvent	[Reaction:R-DME-9009065] FOXA1 and GATA3 bind to CCND1 promoter - Drosophila melanogaster [Reaction:R-GGA-9009065] FOXA1 and GATA3 bind to CCND1 promoter - Gallus gallus [Reaction:R-XTR-9009065] FOXA1 and GATA3 bind to CCND1 promoter - Xenopus tropicalis [Reaction:R-DRE-9009065] FOXA1 and GATA3 bind to CCND1 promoter - Danio rerio [Reaction:R-SSC-9009065] FOXA1 and GATA3 bind to CCND1 promoter - Sus scrofa [Reaction:R-BTA-9009065] FOXA1 and GATA3 bind to CCND1 promoter - Bos taurus [Reaction:R-CFA-9009065] FOXA1 and GATA3 bind to CCND1 promoter - Canis familiaris [Reaction:R-RNO-9009065] FOXA1 and GATA3 bind to CCND1 promoter - Rattus norvegicus
output	[Complex:R-HSA-9009057] CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-205021] HDAC1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-4086091] YY1 [nucleoplasm]
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9038169] Magnani, Luca, 2018-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9009065
summation	[Summation:9009063] Estrogen induces cellular proliferation by upregulating expr...

Referrals

(hasEvent)	[Pathway:R-HSA-9018519] Estrogen-dependent gene expression
(precedingEvent)	[Reaction:R-HSA-9009371] Binding of AP1 transcriptional activator complexes to CCND1 promoter

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