Reactome | ESR dimerizes

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ESR dimerizes Show undefined attributes

authored	[InstanceEdit:9024061] Rothfels, Karen, 2017-09-29
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8939206] Rothfels, Karen, 2016-09-16
dbId	8939201
displayName	ESR dimerizes
edited	[InstanceEdit:9027686] Rothfels, Karen, 2017-11-03
eventOf	[Pathway:R-HSA-8939211] ESR-mediated signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-9023845] ESR1:ESTG binds to proximal and distal regions of the CTSD promoter - Homo sapiens [Reaction:R-HSA-9018325] ESR1:ESTG binds CXXC5 gene - Homo sapiens [Reaction:R-HSA-9011952] ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers - Homo sapiens [Reaction:R-HSA-9011997] ESR1:ESTG, JUND:FOSB and Cohesin Complex bind distal enhancer elements in MYC gene promoter - Homo sapiens [Reaction:R-HSA-9011983] Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes - Homo sapiens [Reaction:R-HSA-9018503] ESR1:ESTG bind the EBAG9 5' region - Homo sapiens [Reaction:R-HSA-8932070] ESR1 binds the AXIN1 gene - Homo sapiens [Reaction:R-HSA-9018499] ESR1:ESTG and EP300 are recruited to TFF3 promoter - Homo sapiens [Reaction:R-HSA-8931981] RUNX1 binds ESR1 - Homo sapiens [Reaction:R-HSA-1254386] ERBB4s80 forms a complex with estrogen receptor ESR1 - Homo sapiens [Reaction:R-HSA-9009371] Binding of AP1 transcriptional activator complexes to CCND1 promoter - Homo sapiens
input	2 × [DefinedSet:R-HSA-9709550] ESR:ESTG [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8939266] Analysis of oestrogen receptor dimerisation using chimeric proteins [LiteratureReference:8939299] The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements [LiteratureReference:8939279] Dimerizing the estrogen receptor DNA binding domain enhances binding to estrogen response elements [LiteratureReference:8939302] The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer [LiteratureReference:8939275] Differential requirements of Hsp90 and DNA for the formation of estrogen receptor homodimers and heterodimers [LiteratureReference:8937304] Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions [LiteratureReference:8937263] Breast cancer, estrogen receptor and ligands [LiteratureReference:8939288] Identification of estrogen-responsive genes based on the DNA binding properties of estrogen receptors using high-throughput sequencing technology [LiteratureReference:8939282] Estrogen receptor-mediated long-range chromatin interactions and transcription in breast cancer [LiteratureReference:9038047] Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor [LiteratureReference:9038143] Progesterone receptor modulates ER? action in breast cancer [LiteratureReference:9038268] A comprehensive nuclear receptor network for breast cancer cells [LiteratureReference:9038209] Proteomic analysis of coregulators bound to ER? on DNA and nucleosomes reveals coregulator dynamics [LiteratureReference:9038258] Enhancer activation requires trans-recruitment of a mega transcription factor complex [LiteratureReference:8937383] Chromatin and epigenetic determinants of estrogen receptor alpha (ESR1) signaling
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	ESR dimerizes
orthologousEvent	[Reaction:R-DME-8939201] ESR dimerizes - Drosophila melanogaster [Reaction:R-GGA-8939201] ESR dimerizes - Gallus gallus [Reaction:R-XTR-8939201] ESR dimerizes - Xenopus tropicalis [Reaction:R-DRE-8939201] ESR dimerizes - Danio rerio [Reaction:R-SSC-8939201] ESR dimerizes - Sus scrofa [Reaction:R-BTA-8939201] ESR dimerizes - Bos taurus [Reaction:R-CFA-8939201] ESR dimerizes - Canis familiaris [Reaction:R-RNO-8939201] ESR dimerizes - Rattus norvegicus [Reaction:R-MMU-8939201] ESR dimerizes - Mus musculus
output	[DefinedSet:R-HSA-9710004] ESR multimer:ESTG [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8939203] HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex - Homo sapiens
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9038169] Magnani, Luca, 2018-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8939201
summation	[Summation:8939200] Upon ligand binding, estrogen receptors form homo- or hetero...
updateTrackers	[UpdateTracker:9776357] Update Tracker - [Reaction:8939201] ESR dimerizes - v76:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9776357] Update Tracker - [Reaction:8939201] ESR dimerizes - v76:[add_removeInput, add_removeOutput]
(precedingEvent)	[Reaction:R-HSA-9023845] ESR1:ESTG binds to proximal and distal regions of the CTSD promoter [Reaction:R-HSA-9018325] ESR1:ESTG binds CXXC5 gene [Reaction:R-HSA-9011952] ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers [Reaction:R-HSA-9011997] ESR1:ESTG, JUND:FOSB and Cohesin Complex bind distal enhancer elements in MYC gene promoter [Reaction:R-HSA-9018499] ESR1:ESTG and EP300 are recruited to TFF3 promoter [Reaction:R-HSA-9011983] Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes [Reaction:R-HSA-9018503] ESR1:ESTG bind the EBAG9 5' region [Reaction:R-HSA-8931981] RUNX1 binds ESR1 [Reaction:R-HSA-8932070] ESR1 binds the AXIN1 gene [Reaction:R-HSA-1254386] ERBB4s80 forms a complex with estrogen receptor ESR1 [Reaction:R-HSA-9009371] Binding of AP1 transcriptional activator complexes to CCND1 promoter
(hasEvent)	[Pathway:R-HSA-8939211] ESR-mediated signaling

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