Reactome | Interleukin-15 signaling

Schema > Pathway > Entries

Interleukin-15 signaling Show undefined attributes

created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10650384
displayName	Interleukin-15 signaling
eventOf	[Pathway:R-DRE-451927] Interleukin-2 family signaling - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:1301068] interleukin-15-mediated signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DRE-8983307] IL15 binds IL15RA - Danio rerio [BlackBoxEvent:R-DRE-8983300] IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 - Danio rerio [BlackBoxEvent:R-DRE-8983384] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 - Danio rerio [BlackBoxEvent:R-DRE-8983335] IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome - Danio rerio
inferredFrom	[Pathway:R-HSA-8983432] Interleukin-15 signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Interleukin-15 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-8983432
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-451927] Interleukin-2 family signaling
(inferredTo)	[Pathway:R-HSA-8983432] Interleukin-15 signaling

© 2026 Reactome

Cite Us!