Reactome | cAMP binds PKA tetramer

Schema > Reaction > Entries

cAMP binds PKA tetramer Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11041536
displayName	cAMP binds PKA tetramer
eventOf	[Pathway:R-DDI-432040] Vasopressin regulates renal water homeostasis via Aquaporins - Dictyostelium discoideum [Pathway:R-DDI-163615] PKA activation - Dictyostelium discoideum [Pathway:R-DDI-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-111925] cAMP induces dissociation of inactive PKA tetramers - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-8951727] cAMP binds PKA tetramer - Homo sapiens
input	4 × [SimpleEntity:R-ALL-30389] cAMP [cytosol] [Complex:R-DDI-111922] PKA tetramer [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	cAMP binds PKA tetramer
output	[Complex:R-DDI-8951729] PKA tetramer:4xcAMP [cytosol]
precedingEvent	[Reaction:R-DDI-111930] Adenylate cyclase produces cAMP - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-8951727
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-432040] Vasopressin regulates renal water homeostasis via Aquaporins [Pathway:R-DDI-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells [Pathway:R-DDI-9634597] GPER1 signaling [Pathway:R-DDI-442720] CREB1 phosphorylation through the activation of Adenylate Cyclase [Pathway:R-DDI-180024] DARPP-32 events [Pathway:R-DDI-163615] PKA activation
(precedingEvent)	[Reaction:R-DDI-111925] cAMP induces dissociation of inactive PKA tetramers
(inferredTo)	[Reaction:R-HSA-8951727] cAMP binds PKA tetramer