Reactome | Activated Adenylate cyclase catalyses cAMP synthesis

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Activated Adenylate cyclase catalyses cAMP synthesis Show undefined attributes

authored	[InstanceEdit:164336] Gopinathrao, G, 2005-05-18 22:14:39
catalystActivity	[CatalystActivity:164332] adenylate cyclase activity of G alpha (s):GTP:Adenylate cyclase [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:164336] Gopinathrao, G, 2005-05-18 22:14:39
crossReference	[DatabaseIdentifier:12667476] RHEA:15390 [DatabaseIdentifier:9946421] RHEA:15390
dbId	164377
displayName	Activated Adenylate cyclase catalyses cAMP synthesis
edited	[InstanceEdit:435382] Jupe, S, 2009-09-09
eventOf	[Pathway:R-HSA-164378] PKA activation in glucagon signalling - Homo sapiens [Pathway:R-HSA-432040] Vasopressin regulates renal water homeostasis via Aquaporins - Homo sapiens [Pathway:R-HSA-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells - Homo sapiens
followingEvent	[Reaction:R-HSA-392834] Activation of EPACs by cAMP - Homo sapiens [Reaction:R-HSA-8951727] cAMP binds PKA tetramer - Homo sapiens [Reaction:R-HSA-111962] PDE4A,C,D hydrolyse cAMP - Homo sapiens [Reaction:R-HSA-111955] cAMP hydrolysis by Cam-PDE 1 - Homo sapiens [Reaction:R-HSA-9644869] p-S54-PDE4B hydrolyses cAMP - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8984882] The role of Gs in activation of adenylate cyclase
maxDepth	1
modified	[InstanceEdit:9946420] D'Eustachio, Peter, 2025-04-24
name	Activated Adenylate cyclase catalyses cAMP synthesis ATP => 3',5'-cyclic AMP + diphosphate
output	[SimpleEntity:R-ALL-30389] cAMP [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-HSA-163617] G alpha (s) activates adenylate cyclase - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-164377
summation	[Summation:178371] Activated adenylate cyclase associated with the plasma membr...
updateTrackers	[UpdateTracker:9910986] Update Tracker - [Reaction:164377] Activated Adenylate cyclase catalyses cAMP synthesis - v89:[modifyText] [UpdateTracker:9789596] Update Tracker - [Reaction:164377] Activated Adenylate cyclase catalyses cAMP synthesis - v37:[modifyText] [UpdateTracker:9780926] Update Tracker - [Reaction:164377] Activated Adenylate cyclase catalyses cAMP synthesis - v61:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9910986] Update Tracker - [Reaction:164377] Activated Adenylate cyclase catalyses cAMP synthesis - v89:[modifyText] [UpdateTracker:9789596] Update Tracker - [Reaction:164377] Activated Adenylate cyclase catalyses cAMP synthesis - v37:[modifyText] [UpdateTracker:9780926] Update Tracker - [Reaction:164377] Activated Adenylate cyclase catalyses cAMP synthesis - v61:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-164378] PKA activation in glucagon signalling [Pathway:R-HSA-432040] Vasopressin regulates renal water homeostasis via Aquaporins [Pathway:R-HSA-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
(precedingEvent)	[Reaction:R-HSA-392834] Activation of EPACs by cAMP [Reaction:R-HSA-111962] PDE4A,C,D hydrolyse cAMP [Reaction:R-HSA-9644869] p-S54-PDE4B hydrolyses cAMP [Reaction:R-HSA-111955] cAMP hydrolysis by Cam-PDE 1 [Reaction:R-HSA-8951727] cAMP binds PKA tetramer