Reactome | DARPP-32 events

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DARPP-32 events Show undefined attributes

authored	[InstanceEdit:112007] Le Novere, N, Jassal, B, 2004-03-31 12:22:05
created	[InstanceEdit:180049] Jassal, B, 2006-05-16 12:25:23
dbId	180024
displayName	DARPP-32 events
edited	[InstanceEdit:379927] Jassal, Bijay, 2008-11-06
eventOf	[Pathway:R-HSA-111885] Opioid Signalling - Homo sapiens
figure	[Figure:202036] /figures/SBGNdiag_101007_2.jpg
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-177284] PKA phosphorylates PDE4B - Homo sapiens [Reaction:R-HSA-9644869] p-S54-PDE4B hydrolyses cAMP - Homo sapiens [Reaction:R-HSA-111962] PDE4A,C,D hydrolyse cAMP - Homo sapiens [Reaction:R-HSA-8951727] cAMP binds PKA tetramer - Homo sapiens [Reaction:R-HSA-111925] cAMP induces dissociation of inactive PKA tetramers - Homo sapiens [Reaction:R-HSA-177275] PKA phosphorylates DARPP-32 on Thr34 - Homo sapiens [Reaction:R-HSA-180038] DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function - Homo sapiens [Reaction:R-HSA-180047] CDK5 phosphorylates DARPP-32 on Thr75 - Homo sapiens [Reaction:R-HSA-180073] DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function - Homo sapiens [Reaction:R-HSA-201790] DARPP-32 is dephosphorylated on Thr75 by PP2A - Homo sapiens [Reaction:R-HSA-201783] Inactive catalytic PP2B is activated by the binding of calmodulin - Homo sapiens [Reaction:R-HSA-201787] PPP3 complex dephosphorylates DARPP-32 on Thr34 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-03-29
literatureReference	[LiteratureReference:374094] DARPP-32: an integrator of neurotransmission [LiteratureReference:374084] Neuronal phosphoproteins. Mediators of signal transduction
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	DARPP-32 events
orthologousEvent	[Pathway:R-PFA-180024] DARPP-32 events - Plasmodium falciparum [Pathway:R-SCE-180024] DARPP-32 events - Saccharomyces cerevisiae [Pathway:R-SPO-180024] DARPP-32 events - Schizosaccharomyces pombe [Pathway:R-DDI-180024] DARPP-32 events - Dictyostelium discoideum [Pathway:R-CEL-180024] DARPP-32 events - Caenorhabditis elegans [Pathway:R-DME-180024] DARPP-32 events - Drosophila melanogaster [Pathway:R-GGA-180024] DARPP-32 events - Gallus gallus [Pathway:R-XTR-180024] DARPP-32 events - Xenopus tropicalis [Pathway:R-DRE-180024] DARPP-32 events - Danio rerio [Pathway:R-SSC-180024] DARPP-32 events - Sus scrofa [Pathway:R-BTA-180024] DARPP-32 events - Bos taurus [Pathway:R-CFA-180024] DARPP-32 events - Canis familiaris [Pathway:R-RNO-180024] DARPP-32 events - Rattus norvegicus [Pathway:R-MMU-180024] DARPP-32 events - Mus musculus
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:379937] Castagnoli, L, 2008-11-06 12:55:54
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-180024
summation	[Summation:374114] Dopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARP...
updateTrackers	[UpdateTracker:9863956] Update Tracker - [Pathway:180024] DARPP-32 events - v88:[updateContainedRLE] [UpdateTracker:9786581] Update Tracker - [Pathway:180024] DARPP-32 events - v49:[updateContainedRLE] [UpdateTracker:9846769] Update Tracker - [Pathway:180024] DARPP-32 events - v84:[updateContainedRLE] [UpdateTracker:9778876] Update Tracker - [Pathway:180024] DARPP-32 events - v67:[updateContainedRLE] [UpdateTracker:9788916] Update Tracker - [Pathway:180024] DARPP-32 events - v39:[updateContainedRLE] [UpdateTracker:9777768] Update Tracker - [Pathway:180024] DARPP-32 events - v69:[addHasEvent, updateContainedRLE] [UpdateTracker:9782014] Update Tracker - [Pathway:180024] DARPP-32 events - v60:[addHasEvent, updateContainedRLE]

Referrals

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[Pathway:R-HSA-111885] Opioid Signalling

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