Reactome | CREB1 phosphorylation through the activation of Adenylate Cyclase

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CREB1 phosphorylation through the activation of Adenylate Cyclase Show undefined attributes

authored	[InstanceEdit:445353] Mahajan, SS, 2009-10-29
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:442716] Mahajan, SS, 2009-09-29
dbId	442720
displayName	CREB1 phosphorylation through the activation of Adenylate Cyclase
edited	[InstanceEdit:447013] Gillespie, ME, 2009-11-19 [InstanceEdit:9628239] Orlic-Milacic, Marija, 2018-11-07
eventOf	[Pathway:R-HSA-438064] Post NMDA receptor activation events - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:645] chemical synaptic transmission
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9617535] Activated calmodulin binds ADCY1,ADCY8 - Homo sapiens [Reaction:R-HSA-442715] Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP - Homo sapiens [Reaction:R-HSA-8951727] cAMP binds PKA tetramer - Homo sapiens [Reaction:R-HSA-111925] cAMP induces dissociation of inactive PKA tetramers - Homo sapiens [Reaction:R-HSA-111924] PKA catalytic subunit translocates to the nucleus - Homo sapiens [Reaction:R-HSA-111919] PKA phosphorylates CREB1 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-03-29
literatureReference	[LiteratureReference:443470] RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathway
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	CREB1 phosphorylation through the activation of Adenylate Cyclase
orthologousEvent	[Pathway:R-DDI-442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - Dictyostelium discoideum [Pathway:R-PFA-442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - Plasmodium falciparum [Pathway:R-SCE-442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - Saccharomyces cerevisiae [Pathway:R-SPO-442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - Schizosaccharomyces pombe [Pathway:R-CEL-442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - Caenorhabditis elegans [Pathway:R-DME-442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - Drosophila melanogaster [Pathway:R-GGA-442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - Gallus gallus [Pathway:R-XTR-442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - Xenopus tropicalis [Pathway:R-DRE-442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - Danio rerio [Pathway:R-SSC-442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - Sus scrofa [Pathway:R-BTA-442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - Bos taurus [Pathway:R-RNO-442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - Rattus norvegicus [Pathway:R-MMU-442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - Mus musculus
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446792] Tukey, D, 2009-11-17 [InstanceEdit:9627687] Yi, Feng, 2018-11-02 [InstanceEdit:9628437] Hansen, Kasper B, 2018-11-02
revised	[InstanceEdit:9624342] Orlic-Milacic, Marija, 2018-10-10
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-442720
summation	[Summation:444270] Ca2+ influx through activated NMDA receptors in the post syn...
updateTrackers	[UpdateTracker:9779235] Update Tracker - [Pathway:442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - v66:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9864155] Update Tracker - [Pathway:442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - v88:[updateContainedRLE] [UpdateTracker:9777096] Update Tracker - [Pathway:442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - v72:[updateContainedRLE] [UpdateTracker:9790578] Update Tracker - [Pathway:442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - v33:[updateContainedRLE] [UpdateTracker:9846784] Update Tracker - [Pathway:442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - v84:[updateContainedRLE] [UpdateTracker:9778917] Update Tracker - [Pathway:442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - v67:[addHasEvent, modifyText, updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9779235] Update Tracker - [Pathway:442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - v66:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9864155] Update Tracker - [Pathway:442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - v88:[updateContainedRLE]
[UpdateTracker:9777096] Update Tracker - [Pathway:442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - v72:[updateContainedRLE]
[UpdateTracker:9790578] Update Tracker - [Pathway:442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - v33:[updateContainedRLE]
[UpdateTracker:9846784] Update Tracker - [Pathway:442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - v84:[updateContainedRLE]
[UpdateTracker:9778917] Update Tracker - [Pathway:442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - v67:[addHasEvent, modifyText, updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-438064] Post NMDA receptor activation events

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