Reactome | SCF(SKP2) complex binds RUNX2

SCF(SKP2) complex binds RUNX2

Stable Identifier

R-HSA-8939688

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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The E3 ubiquitin ligase complex SCF binds RUNX2 through direct interaction between SKP2 subunit of the SCF complex and RUNX2 (Thacker et al. 2016). This process is inhibited by glucose uptake in osteoblasts (Wei et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
26091038	Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation Pessin, JE, Wei, J, Lezaki, T, Hinoi, E, Shimazu, J, Kajimura, D, Karsenty, G, Zong, H, Maurizi, A, Makinistoglu, MP, Takarada, T	Cell	2015
26778333	Skp2 inhibits osteogenesis by promoting ubiquitin-proteasome degradation of Runx2 Khan, MP, Kumar, Y, Trivedi, AK, Kanaujiya, JK, Kapoor, I, Sanyal, S, Thacker, G, Chattopadhyay, N, Lochab, S, Ahmed, S, Shukla, N	Biochim. Biophys. Acta	2016