Reactome | SCF(SKP2) complex binds RUNX2

Schema > Reaction > Entries

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10538771
displayName	SCF(SKP2) complex binds RUNX2
eventOf	[Pathway:R-SSC-8939902] Regulation of RUNX2 expression and activity - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-8939706] SCF(SKP2) polyubiquitinates RUNX2 - Sus scrofa
inferredFrom	[Reaction:R-HSA-8939688] SCF(SKP2) complex binds RUNX2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-9007689] RUNX2 [nucleoplasm] [Complex:R-SSC-8939693] SCF (SKP2) complex [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	SCF(SKP2) complex binds RUNX2
output	[Complex:R-SSC-8939702] RUNX2:SCF(SKP2) [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-8939688
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SSC-8939902] Regulation of RUNX2 expression and activity
(precedingEvent)	[Reaction:R-SSC-8939706] SCF(SKP2) polyubiquitinates RUNX2
(inferredTo)	[Reaction:R-HSA-8939688] SCF(SKP2) complex binds RUNX2

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