Reactome | RUNX3 [nucleoplasm]

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-8951514] RUNX3:CTNNB1:TCF7L2,(LEF1) [nucleoplasm] - Homo sapiens [Complex:R-HSA-9945887] TBX21:RUNX3:IL4 gene [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-8952419] SMURFs ubiquitinate RUNX3 - Homo sapiens [Reaction:R-HSA-8952371] MDM2 binds RUNX3 - Homo sapiens [Reaction:R-HSA-8878220] RUNX3 binds the NOTCH1 coactivator complex - Homo sapiens [Reaction:R-HSA-8878193] RUNX3 binds the JAG1 gene promoter - Homo sapiens [Reaction:R-HSA-8952128] RUNX3 binds TP53 - Homo sapiens [BlackBoxEvent:R-HSA-8878117] RUNX3 binds ZFHX3 - Homo sapiens [Reaction:R-HSA-8878143] RUNX3 binds SMAD3 and SMAD4 - Homo sapiens [Reaction:R-HSA-8951676] RUNX3 binds TEADs and YAP1 - Homo sapiens [Reaction:R-HSA-8951428] RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) - Homo sapiens [Reaction:R-HSA-8865454] CBFB binds RUNX3 - Homo sapiens [Reaction:R-HSA-9945877] TBX21 and RUNX3 bind the IL4 gene - Homo sapiens [Reaction:R-HSA-9942723] TBX21 and RUNX3 bind the IFNG gene - Homo sapiens
created	[InstanceEdit:8865392] Orlic-Milacic, Marija, 2016-03-22
dbId	8865393
displayName	RUNX3 [nucleoplasm]
endCoordinate	415
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-8865393] Runx3 [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-RNO-8865393] RUNX3 [nucleoplasm] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-8865393] RUNX3 [nucleoplasm] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-8865393] RUNX3 [nucleoplasm] - Bos taurus [EntityWithAccessionedSequence:R-SSC-8865393] RUNX3 [nucleoplasm] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-8865393] RUNX3 [nucleoplasm] - Danio rerio [EntityWithAccessionedSequence:R-XTR-8865393] RUNX3 [nucleoplasm] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-8865393] RUNX3 [nucleoplasm] - Gallus gallus [EntityWithAccessionedSequence:R-DME-8865393] run [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-8865393] RUNX3 [nucleoplasm] - Caenorhabditis elegans
maxDepth	1
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15
name	RUNX3 Runt-related transcription factor 3 RUNX3_HUMAN AML2 Acute myeloid leukemia 2 protein CBF-alpha-3 CBFA3 AML-2 Polyomavirus enhancer-binding protein 2 alpha C subunit PEA2-alpha C PEBP2-alpha C PEBP2A3 SL3-3 enhancer factor 1 alpha C subunit SL3/AKV core-binding factor alpha C subunit
producedByEvent	[Reaction:R-HSA-8937814] RUNX3 translocates to the nucleus - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:Q13761] UniProt:Q13761 RUNX3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-8865393
startCoordinate	1

(hasComponent)	[Complex:R-HSA-9945887] TBX21:RUNX3:IL4 gene [nucleoplasm] [Complex:R-HSA-9942697] TBX21:RUNX3:IFNG gene [nucleoplasm] [Complex:R-HSA-8951514] RUNX3:CTNNB1:TCF7L2,(LEF1) [nucleoplasm] [Complex:R-HSA-8952373] RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm] [Complex:R-HSA-8878230] RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] [Complex:R-HSA-8878200] RUNX3:JAG1 gene [nucleoplasm] [Complex:R-HSA-8952123] RUNX3:TP53 tetramer [nucleoplasm] [Complex:R-HSA-8878120] RUNX3:ZFHX3 [nucleoplasm] [Complex:R-HSA-8878146] RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] [Complex:R-HSA-8951679] RUNX3:YAP1:TEAD1,TEAD4,(TEAD2,TEAD3) [nucleoplasm] [Complex:R-HSA-8951432] RUNX3:CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] [Complex:R-HSA-8951528] RUNX3:TCF7L2,(LEF1,TCF7L1) [nucleoplasm] [Complex:R-HSA-8865463] RUNX3:CBFB [nucleoplasm]
(input)	[Reaction:R-HSA-9945877] TBX21 and RUNX3 bind the IL4 gene [Reaction:R-HSA-9942723] TBX21 and RUNX3 bind the IFNG gene [Reaction:R-HSA-8952419] SMURFs ubiquitinate RUNX3 [Reaction:R-HSA-8952371] MDM2 binds RUNX3 [Reaction:R-HSA-8878220] RUNX3 binds the NOTCH1 coactivator complex [Reaction:R-HSA-8878193] RUNX3 binds the JAG1 gene promoter [Reaction:R-HSA-8952128] RUNX3 binds TP53 [BlackBoxEvent:R-HSA-8878117] RUNX3 binds ZFHX3 [Reaction:R-HSA-8878143] RUNX3 binds SMAD3 and SMAD4 [Reaction:R-HSA-8865454] CBFB binds RUNX3 [Reaction:R-HSA-8951676] RUNX3 binds TEADs and YAP1 [Reaction:R-HSA-8951428] RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)
(activeUnit)	[PositiveGeneExpressionRegulation:9942741] Positive gene expression regulation by 'TBX21:RUNX3:IFNG gene [nucleoplasm]' [NegativeGeneExpressionRegulation:R-HSA-8878211] Negative gene expression regulation by 'RUNX3:JAG1 gene [nucleoplasm]'
(output)	[Reaction:R-HSA-8937814] RUNX3 translocates to the nucleus

RUNX3 [nucleoplasm] Show undefined attributes

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