Reactome | RUNX3:NOTCH1 Coactivator Complex [nucleoplasm]

Schema > Complex > Entries

RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-8878239] RUNX3:NOTCH1 coactivator complex:HES1 gene [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-8878237] RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter - Homo sapiens
created	[InstanceEdit:8878222] Orlic-Milacic, Marija, 2016-06-30
dbId	8878230
displayName	RUNX3:NOTCH1 Coactivator Complex [nucleoplasm]
hasComponent	[Complex:R-HSA-1604462] NOTCH1 Coactivator Complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8865393] RUNX3 [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-8878230] RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] - Mus musculus [Complex:R-RNO-8878230] RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-8878230] RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] - Canis familiaris [Complex:R-BTA-8878230] RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] - Bos taurus [Complex:R-SSC-8878230] RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] - Sus scrofa [Complex:R-XTR-8878230] RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] - Xenopus tropicalis [Complex:R-GGA-8878230] RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] - Gallus gallus [Complex:R-DME-8878230] RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] - Drosophila melanogaster [Complex:R-CEL-8878230] RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] - Caenorhabditis elegans
isChimeric	false
literatureReference	[LiteratureReference:8878223] RUNX3 directly interacts with intracellular domain of Notch1 and suppresses Notch signaling in hepatocellular carcinoma cells
maxDepth	4
modified	[InstanceEdit:8959866] Orlic-Milacic, Marija, 2017-01-31
name	RUNX3:NOTCH1 Coactivator Complex
producedByEvent	[Reaction:R-HSA-8878220] RUNX3 binds the NOTCH1 coactivator complex - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-8878230

Referrals

(output)	[Reaction:R-HSA-8878220] RUNX3 binds the NOTCH1 coactivator complex
(input)	[Reaction:R-HSA-8878237] RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter
(hasComponent)	[Complex:R-HSA-8878239] RUNX3:NOTCH1 coactivator complex:HES1 gene [nucleoplasm]
(activeUnit)	[NegativeGeneExpressionRegulation:R-HSA-8878245] Negative gene expression regulation by 'RUNX3:NOTCH1 coactivator complex:HES1 gene [nucleoplasm]'

© 2026 Reactome

Cite Us!