Reactome | SMURFs ubiquitinate RUNX3

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SMURFs ubiquitinate RUNX3 Show undefined attributes

authored	[InstanceEdit:8951943] Orlic-Milacic, Marija, 2016-12-12
catalystActivity	[CatalystActivity:8952414] ubiquitin protein ligase activity of SMURF [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8952416] Orlic-Milacic, Marija, 2016-12-14
dbId	8952419
displayName	SMURFs ubiquitinate RUNX3
edited	[InstanceEdit:8959863] Orlic-Milacic, Marija, 2017-01-31
eventOf	[Pathway:R-HSA-8941858] Regulation of RUNX3 expression and activity - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8865393] RUNX3 [nucleoplasm] 3 × [DefinedSet:R-HSA-68524] Ub [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8951953] Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	SMURFs ubiquitinate RUNX3
orthologousEvent	[Reaction:R-DME-8952419] SMURFs ubiquitinate RUNX3 - Drosophila melanogaster [Reaction:R-GGA-8952419] SMURFs ubiquitinate RUNX3 - Gallus gallus [Reaction:R-XTR-8952419] SMURFs ubiquitinate RUNX3 - Xenopus tropicalis [Reaction:R-DRE-8952419] SMURFs ubiquitinate RUNX3 - Danio rerio [Reaction:R-SSC-8952419] SMURFs ubiquitinate RUNX3 - Sus scrofa [Reaction:R-BTA-8952419] SMURFs ubiquitinate RUNX3 - Bos taurus [Reaction:R-CFA-8952419] SMURFs ubiquitinate RUNX3 - Canis familiaris [Reaction:R-RNO-8952419] SMURFs ubiquitinate RUNX3 - Rattus norvegicus [Reaction:R-MMU-8952419] SMURFs ubiquitinate RUNX3 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-8952417] PolyUb-RUNX3 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8937814] RUNX3 translocates to the nucleus - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-8952420] Negative regulation by 'EP300 [nucleoplasm]'
regulationReference	[RegulationReference:9641748] Negative regulation by 'EP300 [nucleoplasm]' Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8959885] Ito, Yoshiaki, 2017-01-31 [InstanceEdit:8959883] Chuang, Linda Shyue Huey, 2017-01-31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8952419
summation	[Summation:8952418] SMURF1 and SMURF2 polyubiquitinate RUNX3 on unknown lysine r...
updateTrackers	[UpdateTracker:9778185] Update Tracker - [Reaction:8952419] SMURFs ubiquitinate RUNX3 - v68:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9778185] Update Tracker - [Reaction:8952419] SMURFs ubiquitinate RUNX3 - v68:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-8941858] Regulation of RUNX3 expression and activity