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Schema
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Reaction
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Entries
RUNX3 binds the NOTCH1 coactivator complex
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authored
[InstanceEdit:8951943] Orlic-Milacic, Marija, 2016-12-12
category
binding
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:8878222] Orlic-Milacic, Marija, 2016-06-30
dbId
8878220
displayName
RUNX3 binds the NOTCH1 coactivator complex
edited
[InstanceEdit:8959863] Orlic-Milacic, Marija, 2017-01-31
eventOf
[Pathway:R-HSA-8941856] RUNX3 regulates NOTCH signaling - Homo sapiens
followingEvent
[Reaction:R-HSA-8878237] RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter - Homo sapiens
input
[Complex:R-HSA-1604462] NOTCH1 Coactivator Complex [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-8865393] RUNX3 [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8878223] RUNX3 directly interacts with intracellular domain of Notch1 and suppresses Notch signaling in hepatocellular carcinoma cells
maxDepth
1
modified
[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name
RUNX3 binds the NOTCH1 coactivator complex
orthologousEvent
[Reaction:R-GGA-8878220] RUNX3 binds the NOTCH1 coactivator complex - Gallus gallus
[Reaction:R-XTR-8878220] RUNX3 binds the NOTCH1 coactivator complex - Xenopus tropicalis
[Reaction:R-SSC-8878220] RUNX3 binds the NOTCH1 coactivator complex - Sus scrofa
[Reaction:R-BTA-8878220] RUNX3 binds the NOTCH1 coactivator complex - Bos taurus
[Reaction:R-CFA-8878220] RUNX3 binds the NOTCH1 coactivator complex - Canis familiaris
[Reaction:R-RNO-8878220] RUNX3 binds the NOTCH1 coactivator complex - Rattus norvegicus
[Reaction:R-MMU-8878220] RUNX3 binds the NOTCH1 coactivator complex - Mus musculus
output
[Complex:R-HSA-8878230] RUNX3:NOTCH1 Coactivator Complex [nucleoplasm]
precedingEvent
[Reaction:R-HSA-1912394] NICD1 in complex with RBPJ (CSL) recruits MAML - Homo sapiens
[Reaction:R-HSA-8937814] RUNX3 translocates to the nucleus - Homo sapiens
releaseDate
2017-03-27
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8959885] Ito, Yoshiaki, 2017-01-31
[InstanceEdit:8959883] Chuang, Linda Shyue Huey, 2017-01-31
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-8878220
summation
[Summation:8878235] RUNX3 binds the NOTCH1 coactivator complex by directly inter...
Referrals
(hasEvent)
[Pathway:R-HSA-8941856] RUNX3 regulates NOTCH signaling
(precedingEvent)
[Reaction:R-HSA-8878237] RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter
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