Reactome | RUNX3 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-CFA-8952373] RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm] - Canis familiaris
consumedByEvent	[Reaction:R-CFA-8952419] SMURFs ubiquitinate RUNX3 - Canis familiaris [Reaction:R-CFA-8952371] MDM2 binds RUNX3 - Canis familiaris [Reaction:R-CFA-8878220] RUNX3 binds the NOTCH1 coactivator complex - Canis familiaris [Reaction:R-CFA-8952128] RUNX3 binds TP53 - Canis familiaris [BlackBoxEvent:R-CFA-8878117] RUNX3 binds ZFHX3 - Canis familiaris [Reaction:R-CFA-8878143] RUNX3 binds SMAD3 and SMAD4 - Canis familiaris [Reaction:R-CFA-8951676] RUNX3 binds TEADs and YAP1 - Canis familiaris [Reaction:R-CFA-8951428] RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) - Canis familiaris [Reaction:R-CFA-8865454] CBFB binds RUNX3 - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10308938
displayName	RUNX3 [nucleoplasm]
endCoordinate	415
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-8865393] RUNX3 [nucleoplasm] - Homo sapiens
maxDepth	1
name	RUNX3 A0A8I3NME1
producedByEvent	[Reaction:R-CFA-8937814] RUNX3 translocates to the nucleus - Canis familiaris
referenceEntity	[ReferenceGeneProduct:uniprot:A0A8I3NME1] UniProt:A0A8I3NME1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49646] Canis familiaris
stId	R-CFA-8865393
startCoordinate	1

(input)	[Reaction:R-CFA-8952419] SMURFs ubiquitinate RUNX3 [Reaction:R-CFA-8952371] MDM2 binds RUNX3 [Reaction:R-CFA-8878220] RUNX3 binds the NOTCH1 coactivator complex [Reaction:R-CFA-8952128] RUNX3 binds TP53 [BlackBoxEvent:R-CFA-8878117] RUNX3 binds ZFHX3 [Reaction:R-CFA-8878143] RUNX3 binds SMAD3 and SMAD4 [Reaction:R-CFA-8865454] CBFB binds RUNX3 [Reaction:R-CFA-8951676] RUNX3 binds TEADs and YAP1 [Reaction:R-CFA-8951428] RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)
(hasComponent)	[Complex:R-CFA-8952373] RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm] [Complex:R-CFA-8878230] RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] [Complex:R-CFA-8952123] RUNX3:TP53 tetramer [nucleoplasm] [Complex:R-CFA-8878120] RUNX3:ZFHX3 [nucleoplasm] [Complex:R-CFA-8878146] RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] [Complex:R-CFA-8951679] RUNX3:YAP1:TEAD1,TEAD4,(TEAD2,TEAD3) [nucleoplasm] [Complex:R-CFA-8951432] RUNX3:CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] [Complex:R-CFA-8865463] RUNX3:CBFB [nucleoplasm]
(output)	[Reaction:R-CFA-8937814] RUNX3 translocates to the nucleus
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-8865393] RUNX3 [nucleoplasm]

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