Reactome | 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1

Schema > Reaction > Entries

2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10076676
displayName	2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1
eventOf	[Pathway:R-MMU-8853659] RET signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5672965] RAS GEFs promote RAS nucleotide exchange - Mus musculus
inferredFrom	[Reaction:R-HSA-8854899] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 - Homo sapiens
input	[Complex:R-MMU-8854160] 2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] [Complex:R-MMU-109797] GRB2-1:SOS1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1
output	[Complex:R-MMU-8854903] 2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane]
precedingEvent	[Reaction:R-MMU-8853792] RET tyrosine phosphorylation - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8854899
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8853659] RET signaling
(precedingEvent)	[Reaction:R-MMU-5672965] RAS GEFs promote RAS nucleotide exchange
(inferredTo)	[Reaction:R-HSA-8854899] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1

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