Reactome | Dephosphorylation of JAKs by PTPs

Schema > Reaction > Entries

authored	[InstanceEdit:873929] Garapati, P V, 2010-06-08
catalystActivity	[CatalystActivity:997306] protein tyrosine phosphatase activity of PTPs-SHP1/2/PTP1B [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:877278] Garapati, P V, 2010-06-11
dbId	877308
displayName	Dephosphorylation of JAKs by PTPs
edited	[InstanceEdit:909728] Garapati, P V, 2010-07-07
eventOf	[Pathway:R-HSA-877312] Regulation of IFNG signaling - Homo sapiens
inferredFrom	[Reaction:R-MMU-877301] Dephosphorylation of Jaks by Ptps - Mus musculus
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-873820] IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dephosphorylation of JAKs by PTPs
output	[Complex:R-HSA-873829] IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane] 2 × [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-873918] Transphosphorylation of JAK1 - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:933762] Abdul-Sater, AA, Schindler, C, 2010-08-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-877308
summation	[Summation:877298] Protein tyrosine phosphatases (PTPs) SHP1 and SHP2 down regu...

(hasEvent)	[Pathway:R-HSA-877312] Regulation of IFNG signaling
(inferredTo)	[Reaction:R-MMU-877301] Dephosphorylation of Jaks by Ptps

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