Reactome | Transphosphorylation of JAK1

Schema > Reaction > Entries

Transphosphorylation of JAK1 Show undefined attributes

catalystActivity	[CatalystActivity:10351708] protein tyrosine kinase activity of IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10314670] Wright, Adam, 2024-03-07
dbId	10351722
displayName	Transphosphorylation of JAK1
eventOf	[Pathway:R-SSC-877300] Interferon gamma signaling - Sus scrofa
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-873924] Phosphorylation of IFNGR1 by JAK kinases - Sus scrofa [BlackBoxEvent:R-SSC-9734547] JAK2-activated MAPKs phosphorylate YBX1 - Sus scrofa
inferredFrom	[Reaction:R-HSA-873918] Transphosphorylation of JAK1 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-SSC-873811] IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane]
isInDisease	false
isInferred	true
name	Transphosphorylation of JAK1
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-SSC-873820] IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane]
precedingEvent	[Reaction:R-SSC-873919] Phosphorylation of JAK2 - Sus scrofa
regulatedBy	[NegativeRegulation:10351723] Negative regulation by 'PTPN6 [cytosol]' [NegativeRegulation:10351724] Negative regulation by 'IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane]'
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-873918
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-877300] Interferon gamma signaling
(precedingEvent)	[BlackBoxEvent:R-SSC-9734547] JAK2-activated MAPKs phosphorylate YBX1 [Reaction:R-SSC-873924] Phosphorylation of IFNGR1 by JAK kinases
(inferredTo)	[Reaction:R-HSA-873918] Transphosphorylation of JAK1