Transport of Citrate from Mitochondrial Matrix to cytosol

Stable Identifier
Reaction [transition]
Homo sapiens
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SLC25A1, in the inner mitochondrial membrane, mediates the exchange of mitochondrial citrate for cytosolic malate (Edvarson et al.2013, Gnoni et al.2009).

Literature References
PubMed ID Title Journal Year
23393310 Agenesis of corpus callosum and optic nerve hypoplasia due to mutations in SLC25A1 encoding the mitochondrial citrate transporter

Elpeleg, O, Kellner, Y, Schechter, A, Palmieri, L, Shaag, A, Saada, A, Fraenkel, ND, Edvardson, S, Scarcia, P, Frumkin, A, Korman, SH, Segel, R, Pierri, CL, Soiferman, D, Pines, O, Jalas, C, Porcelli, V

J. Med. Genet. 2013
19787704 The mitochondrial citrate carrier: metabolic role and regulation of its activity and expression

Siculella, L, Geelen, MJ, Priore, P, Gnoni, GV

IUBMB Life 2009
Catalyst Activity

tricarboxylic acid transmembrane transporter activity of SLC25A1 [mitochondrial inner membrane]

Orthologous Events
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