Reactome | CS acetylates OA to citrate

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CS acetylates OA to citrate Show undefined attributes

catalystActivity	[CatalystActivity:70974] citrate (Si)-synthase activity of N6,N6,N6-trimethyl-K395-CS dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:9854189] RHEA:16846 [DatabaseIdentifier:11881133] Rhea:16846
dbId	70975
displayName	CS acetylates OA to citrate
eventOf	[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle) - Homo sapiens
followingEvent	[Reaction:R-HSA-75849] SLC25A1 exchanges CIT and MAL - Homo sapiens [Reaction:R-HSA-70971] ACO2 isomerizes citrate - Homo sapiens
input	[SimpleEntity:R-ALL-113559] Ac-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113587] OA [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9853599] Complexes between mitochondrial enzymes and either citrate synthase or glutamate dehydrogenase [LiteratureReference:198413] Cloning and molecular analysis of the human citrate synthase gene [LiteratureReference:9854357] Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation [LiteratureReference:198427] Interaction between citrate synthase and malate dehydrogenase. Substrate channeling of oxaloacetate [LiteratureReference:9853598] Association of the malate dehydrogenase-citrate synthase metabolon is modulated by intermediates of the Krebs tricarboxylic acid cycle [LiteratureReference:9853591] Krebs cycle metabolon: structural evidence of substrate channeling revealed by cross-linking and mass spectrometry
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	CS acetylates OA to citrate acetyl-CoA + H2O + oxaloacetate => citrate + CoA + H(+)
orthologousEvent	[Reaction:R-MMU-70975] CS acetylates OA to citrate - Mus musculus [Reaction:R-RNO-70975] CS acetylates OA to citrate - Rattus norvegicus [Reaction:R-PFA-70975] CS acetylates OA to citrate - Plasmodium falciparum [Reaction:R-CFA-70975] CS acetylates OA to citrate - Canis familiaris [Reaction:R-GGA-70975] CS acetylates OA to citrate - Gallus gallus [Reaction:R-XTR-70975] CS acetylates OA to citrate - Xenopus tropicalis [Reaction:R-DRE-70975] CS acetylates OA to citrate - Danio rerio [Reaction:R-BTA-70975] CS acetylates OA to citrate - Bos taurus [Reaction:R-DDI-70975] CS acetylates OA to citrate - Dictyostelium discoideum [Reaction:R-SSC-70975] CS acetylates OA to citrate - Sus scrofa [Reaction:R-SPO-70975] CS acetylates OA to citrate - Schizosaccharomyces pombe [Reaction:R-DME-70975] CS acetylates OA to citrate - Drosophila melanogaster [Reaction:R-SCE-70975] CS acetylates OA to citrate - Saccharomyces cerevisiae [Reaction:R-CEL-70975] CS acetylates OA to citrate - Caenorhabditis elegans
output	[SimpleEntity:R-ALL-29654] CIT [mitochondrial matrix] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-70979] MDH2 dimer dehydrogenates MAL - Homo sapiens [Reaction:R-HSA-70844] alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA - Homo sapiens [Reaction:R-HSA-9854315] CSKMT methylates Citrate Synthase - Homo sapiens [Reaction:R-HSA-70501] PC carboxylates PYR to OA - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9861215] Hill, David P, 2024-02-15
revised	[InstanceEdit:451045] D'Eustachio, P, 2009-12-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70975
summation	[Summation:71414] Mitochondrial citrate synthase (CS) dimer catalyzes the irre...

Referrals

(precedingEvent)	[Reaction:R-HSA-75849] SLC25A1 exchanges CIT and MAL [Reaction:R-HSA-70971] ACO2 isomerizes citrate
(hasEvent)	[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle)

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