Reactome | The Ligand:GPCR:Gi complex dissociates

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The Ligand:GPCR:Gi complex dissociates Show undefined attributes

authored	[InstanceEdit:744889] Jupe, S, 2010-05-18
category	dissociation
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:749449] Jupe, S, 2010-05-18
dbId	749454
displayName	The Ligand:GPCR:Gi complex dissociates
edited	[InstanceEdit:813668] Jupe, S, 2010-05-26
eventOf	[Pathway:R-HSA-418594] G alpha (i) signalling events - Homo sapiens
followingEvent	[Reaction:R-HSA-8982019] Active G alpha (i)?i1/i2/i3 binds RGS proteins - Homo sapiens [Reaction:R-HSA-8964311] G alpha (i):GTP binds SRC - Homo sapiens [Reaction:R-HSA-392212] G alpha (i) auto-inactivates by hydrolysing GTP to GDP - Homo sapiens [Reaction:R-HSA-392206] G alpha (i) inhibits adenylate cyclase - Homo sapiens [Reaction:R-HSA-392295] Gbeta:gamma recruits PI3K gamma - Homo sapiens [Reaction:R-HSA-8964241] G beta-gamma complex and PIP3 recruit BTK to membrane - Homo sapiens [Reaction:R-HSA-398040] Gbeta:gamma activation of PLC beta - Homo sapiens [Reaction:R-HSA-8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex - Homo sapiens
input	[Complex:R-HSA-749445] Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:427945] Dissociation of heterotrimeric g proteins in cells
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	The Ligand:GPCR:Gi complex dissociates
orthologousEvent	[Reaction:R-CEL-749454] The Ligand:GPCR:Gi complex dissociates - Caenorhabditis elegans [Reaction:R-GGA-749454] The Ligand:GPCR:Gi complex dissociates - Gallus gallus [Reaction:R-BTA-749454] The Ligand:GPCR:Gi complex dissociates - Bos taurus [Reaction:R-CFA-749454] The Ligand:GPCR:Gi complex dissociates - Canis familiaris [Reaction:R-MMU-749454] The Ligand:GPCR:Gi complex dissociates - Mus musculus
output	[Complex:R-HSA-392161] G alpha (i): GTP [plasma membrane] [Complex:R-HSA-167434] G-protein beta-gamma complex [plasma membrane] [DefinedSet:R-HSA-380091] Ligand:GPCR complexes that activate Gi [plasma membrane]
precedingEvent	[Reaction:R-HSA-380073] Liganded Gi-activating GPCR acts as a GEF for Gi - Homo sapiens
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:782850] D'Eustachio, P, 2010-05-21
revised	[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-749454
summation	[Summation:804955] The classical view of G-protein signalling is that the G-pro...
updateTrackers	[UpdateTracker:9776975] Update Tracker - [Reaction:749454] The Ligand:GPCR:Gi complex dissociates - v73:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9776975] Update Tracker - [Reaction:749454] The Ligand:GPCR:Gi complex dissociates - v73:[add_removeOutput]
(precedingEvent)	[Reaction:R-HSA-392212] G alpha (i) auto-inactivates by hydrolysing GTP to GDP [Reaction:R-HSA-392206] G alpha (i) inhibits adenylate cyclase [Reaction:R-HSA-8982019] Active G alpha (i)?i1/i2/i3 binds RGS proteins [Reaction:R-HSA-8964311] G alpha (i):GTP binds SRC [Reaction:R-HSA-8964241] G beta-gamma complex and PIP3 recruit BTK to membrane [Reaction:R-HSA-8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex [Reaction:R-HSA-392295] Gbeta:gamma recruits PI3K gamma [Reaction:R-HSA-398040] Gbeta:gamma activation of PLC beta
(hasEvent)	[Pathway:R-HSA-418594] G alpha (i) signalling events

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