Reactome | The Ligand:GPCR:Gi complex dissociates

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The Ligand:GPCR:Gi complex dissociates Show undefined attributes

category	dissociation
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10762646
displayName	The Ligand:GPCR:Gi complex dissociates
eventOf	[Pathway:R-GGA-418594] G alpha (i) signalling events - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-8982019] Active G alpha (i)?i1/i2/i3 binds RGS proteins - Gallus gallus [Reaction:R-GGA-8964241] G beta-gamma complex and PIP3 recruit BTK to membrane - Gallus gallus [Reaction:R-GGA-392295] Gbeta:gamma recruits PI3K gamma - Gallus gallus [Reaction:R-GGA-398040] Gbeta:gamma activation of PLC beta - Gallus gallus [Reaction:R-GGA-8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex - Gallus gallus
inferredFrom	[Reaction:R-HSA-749454] The Ligand:GPCR:Gi complex dissociates - Homo sapiens
input	[Complex:R-GGA-749445] Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	The Ligand:GPCR:Gi complex dissociates
output	[Complex:R-GGA-392161] G alpha (i): GTP [plasma membrane] [Complex:R-GGA-167434] G-protein beta-gamma complex [plasma membrane] [DefinedSet:R-GGA-380091] Ligand:GPCR complexes that activate Gi [plasma membrane]
precedingEvent	[Reaction:R-GGA-380073] Liganded Gi-activating GPCR acts as a GEF for Gi - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-749454
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-418594] G alpha (i) signalling events
(precedingEvent)	[Reaction:R-GGA-8982019] Active G alpha (i)?i1/i2/i3 binds RGS proteins [Reaction:R-GGA-8964241] G beta-gamma complex and PIP3 recruit BTK to membrane [Reaction:R-GGA-8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex [Reaction:R-GGA-392295] Gbeta:gamma recruits PI3K gamma [Reaction:R-GGA-398040] Gbeta:gamma activation of PLC beta
(inferredTo)	[Reaction:R-HSA-749454] The Ligand:GPCR:Gi complex dissociates