Reactome | G alpha (i) inhibits adenylate cyclase

Schema > Reaction > Entries

G alpha (i) inhibits adenylate cyclase Show undefined attributes

authored	[InstanceEdit:392017] Jupe, S, 2009-02-26 15:48:59
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:392207] Jupe, S, 2009-02-27 15:51:03
dbId	392206
displayName	G alpha (i) inhibits adenylate cyclase
edited	[InstanceEdit:435382] Jupe, S, 2009-09-09
eventOf	[Pathway:R-HSA-170670] Adenylate cyclase inhibitory pathway - Homo sapiens [Pathway:R-HSA-418594] G alpha (i) signalling events - Homo sapiens
followingEvent	[Reaction:R-HSA-170671] G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex - Homo sapiens
inferredFrom	[Reaction:R-NUL-421821] G alpha (i) inhibits adenylate cyclase - Canis familiaris
input	[Complex:R-HSA-170665] Adenylate cyclase (Mg2+ cofactor) [plasma membrane] [Complex:R-HSA-392161] G alpha (i): GTP [plasma membrane]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:374954] Inhibition of adenylyl cyclase by Gi alpha [LiteratureReference:421824] Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases [LiteratureReference:8982636] Mechanism of Galpha i-mediated inhibition of type V adenylyl cyclase
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	G alpha (i) inhibits adenylate cyclase
output	[Complex:R-HSA-396910] G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane]
precedingEvent	[Reaction:R-HSA-392202] Dissociation of the P2Y purinoceptor 12:Gi complex - Homo sapiens [Reaction:R-HSA-749454] The Ligand:GPCR:Gi complex dissociates - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
revised	[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-392206
summation	[Summation:449171] G-proteins in the Gi class inhibit adenylate cyclase activit...
updateTrackers	[UpdateTracker:9791253] Update Tracker - [Reaction:392206] G alpha (i) inhibits adenylate cyclase - v31:[add_removeSummation] [UpdateTracker:9780897] Update Tracker - [Reaction:392206] G alpha (i) inhibits adenylate cyclase - v61:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9791253] Update Tracker - [Reaction:392206] G alpha (i) inhibits adenylate cyclase - v31:[add_removeSummation] [UpdateTracker:9780897] Update Tracker - [Reaction:392206] G alpha (i) inhibits adenylate cyclase - v61:[addLiteratureReference]
(hasEvent)	[Pathway:R-HSA-170670] Adenylate cyclase inhibitory pathway [Pathway:R-HSA-418594] G alpha (i) signalling events
(precedingEvent)	[Reaction:R-HSA-170671] G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex
(inferredTo)	[Reaction:R-NUL-421821] G alpha (i) inhibits adenylate cyclase