Reactome | Active G alpha (i)?i1/i2/i3 binds RGS proteins

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Active G alpha (i)?i1/i2/i3 binds RGS proteins Show undefined attributes

authored	[InstanceEdit:9014287] Varusai, Thawfeek, 2017-07-27
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:8982022] Varusai, Thawfeek, 2017-03-15
dbId	8982019
displayName	Active G alpha (i)?i1/i2/i3 binds RGS proteins
edited	[InstanceEdit:9014287] Varusai, Thawfeek, 2017-07-27
eventOf	[Pathway:R-HSA-418594] G alpha (i) signalling events - Homo sapiens
followingEvent	[Reaction:R-HSA-8982020] G alpha (i)?i1/i2/i3 in G (i):RGS complex is inactivated - Homo sapiens
input	[Complex:R-HSA-392161] G alpha (i): GTP [plasma membrane] [DefinedSet:R-HSA-8982016] RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8949498] Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits [LiteratureReference:8982372] Regulators of G-protein signalling as new central nervous system drug targets
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Active G alpha (i)?i1/i2/i3 binds RGS proteins
orthologousEvent	[Reaction:R-SCE-8982019] Active G alpha (i)?i1/i2/i3 binds RGS proteins - Saccharomyces cerevisiae [Reaction:R-SPO-8982019] Active G alpha (i)?i1/i2/i3 binds RGS proteins - Schizosaccharomyces pombe [Reaction:R-DDI-8982019] Active G alpha (i)?i1/i2/i3 binds RGS proteins - Dictyostelium discoideum [Reaction:R-CEL-8982019] Active G alpha (i)?i1/i2/i3 binds RGS proteins - Caenorhabditis elegans [Reaction:R-DME-8982019] Active G alpha (i)?i1/i2/i3 binds RGS proteins - Drosophila melanogaster [Reaction:R-GGA-8982019] Active G alpha (i)?i1/i2/i3 binds RGS proteins - Gallus gallus [Reaction:R-XTR-8982019] Active G alpha (i)?i1/i2/i3 binds RGS proteins - Xenopus tropicalis [Reaction:R-DRE-8982019] Active G alpha (i)?i1/i2/i3 binds RGS proteins - Danio rerio [Reaction:R-SSC-8982019] Active G alpha (i)?i1/i2/i3 binds RGS proteins - Sus scrofa [Reaction:R-BTA-8982019] Active G alpha (i)?i1/i2/i3 binds RGS proteins - Bos taurus [Reaction:R-CFA-8982019] Active G alpha (i)?i1/i2/i3 binds RGS proteins - Canis familiaris [Reaction:R-RNO-8982019] Active G alpha (i)?i1/i2/i3 binds RGS proteins - Rattus norvegicus [Reaction:R-MMU-8982019] Active G alpha (i)?i1/i2/i3 binds RGS proteins - Mus musculus
output	[Complex:R-HSA-8982011] G alpha (i):GTP:RGS [plasma membrane]
precedingEvent	[Reaction:R-HSA-749454] The Ligand:GPCR:Gi complex dissociates - Homo sapiens
releaseDate	2018-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9618033] Siderovski, David, 2018-09-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8982019
summation	[Summation:8982295] G Protein Coupled Receptors (GPCR) sense extracellular signa...

Referrals

(precedingEvent)	[Reaction:R-HSA-8982020] G alpha (i)?i1/i2/i3 in G (i):RGS complex is inactivated
(hasEvent)	[Pathway:R-HSA-418594] G alpha (i) signalling events