The Ligand:GPCR:Gi complex dissociates

Stable Identifier
R-HSA-749454
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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The Ligand:GPCR:Gi complex dissociates
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The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (i) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).
Literature References
PubMed ID Title Journal Year
18577758 Dissociation of heterotrimeric g proteins in cells

Lambert, NA

Sci Signal 2008
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Orthologous Events
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The Ligand:GPCR:Gi complex dissociates (Mus musculus)
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Authored
Jupe, S  (2010-05-18)
Reviewed
D'Eustachio, P  (2010-05-22)
Created
Jupe, S  (2010-05-18)
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