Reactome | G beta-gamma complex and PIP3 recruit BTK to membrane

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G beta-gamma complex and PIP3 recruit BTK to membrane Show undefined attributes

authored	[InstanceEdit:9014287] Varusai, Thawfeek, 2017-07-27
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8964250] Varusai, Thawfeek, 2017-02-16
dbId	8964241
displayName	G beta-gamma complex and PIP3 recruit BTK to membrane
edited	[InstanceEdit:9014287] Varusai, Thawfeek, 2017-07-27
eventOf	[Pathway:R-HSA-8964315] G beta:gamma signalling through BTK - Homo sapiens
followingEvent	[Reaction:R-HSA-8964271] BTK in PIP3:BTK:G beta-gamma complex is activated - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-197948] BTK [cytosol] [Complex:R-HSA-167434] G-protein beta-gamma complex [plasma membrane] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8964285] Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits [LiteratureReference:8964339] G Protein beta gamma subunits act on the catalytic domain to stimulate Bruton's agammaglobulinemia tyrosine kinase
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	G beta-gamma complex and PIP3 recruit BTK to membrane
orthologousEvent	[Reaction:R-GGA-8964241] G beta-gamma complex and PIP3 recruit BTK to membrane - Gallus gallus [Reaction:R-BTA-8964241] G beta-gamma complex and PIP3 recruit BTK to membrane - Bos taurus [Reaction:R-CFA-8964241] G beta-gamma complex and PIP3 recruit BTK to membrane - Canis familiaris [Reaction:R-MMU-8964241] G beta-gamma complex and PIP3 recruit BTK to membrane - Mus musculus
output	[Complex:R-HSA-8964249] PIP3:BTK:G-protein beta-gamma complex [plasma membrane]
precedingEvent	[Reaction:R-HSA-392202] Dissociation of the P2Y purinoceptor 12:Gi complex - Homo sapiens [Reaction:R-HSA-418576] Dissociation of the P2Y purinoceptor 1:Gq complex - Homo sapiens [Reaction:R-HSA-397891] Thrombin-activated PARs:G12/13 (active) dissociate - Homo sapiens [Reaction:R-HSA-397835] Thrombin-activated PARs:Gq (active) dissociate - Homo sapiens [Reaction:R-HSA-392874] Dissociation of the Prostacyclin receptor:Gs complex - Homo sapiens [Reaction:R-HSA-744886] The Ligand:GPCR:Gs complex dissociates - Homo sapiens [Reaction:R-HSA-749452] The Ligand:GPCR:Gq complex dissociates - Homo sapiens [Reaction:R-HSA-749454] The Ligand:GPCR:Gi complex dissociates - Homo sapiens [Reaction:R-HSA-751024] The Ligand:GPCR:Gz complex dissociates - Homo sapiens [Reaction:R-HSA-751019] The Ligand:GPCR:G12/13 complex dissociates - Homo sapiens [Reaction:R-HSA-3965447] G-protein subunits dissociate from WNT:FZD complex - Homo sapiens
releaseDate	2018-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9618881] Huang, Xin-Yun, 2018-09-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8964241
summation	[Summation:8964309] G-Protein Coupled Receptors (GPCR) sense extracellular signa...

Referrals

(hasEvent)	[Pathway:R-HSA-8964315] G beta:gamma signalling through BTK
(precedingEvent)	[Reaction:R-HSA-8964271] BTK in PIP3:BTK:G beta-gamma complex is activated