Reactome | 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate

Schema > Reaction > Entries

5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate Show undefined attributes

catalystActivity	[CatalystActivity:10654811] amidophosphoribosyltransferase activity of PPAT dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10654813
displayName	5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate
eventOf	[Pathway:R-XTR-73817] Purine ribonucleoside monophosphate biosynthesis - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-73814] 5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi - Xenopus tropicalis [Reaction:R-XTR-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29472] L-Gln [cytosol] [SimpleEntity:R-ALL-73566] PRPP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O => 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate PRPP + H2O + L-Glutamine => 5-Phosphoribosylamine + L-Glutamate + PPi
output	[SimpleEntity:R-ALL-29404] L-Glu [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol] [SimpleEntity:R-ALL-111292] PRA [cytosol]
precedingEvent	[Reaction:R-XTR-111215] PRPS1 dimer pyrophosphorylates R5P using dATP - Xenopus tropicalis [Reaction:R-XTR-73580] PRPS dimers pyrophosphorylate R5P using ATP - Xenopus tropicalis [Reaction:R-XTR-111289] Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-73815
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-XTR-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate [Reaction:R-XTR-73814] 5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi
(hasEvent)	[Pathway:R-XTR-73817] Purine ribonucleoside monophosphate biosynthesis
(inferredTo)	[Reaction:R-HSA-73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate

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