Reactome | Purine ribonucleoside monophosphate biosynthesis

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Purine ribonucleoside monophosphate biosynthesis Show undefined attributes

authored	[InstanceEdit:73784] Jassal, B, 2003-06-26 04:06:16
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73784] Jassal, B, 2003-06-26 04:06:16
dbId	73817
deleted	[Deleted:500271] Deletion of instance: 74226 [Deleted:500269] Deletion of instance: 111585 [Deleted:500270] Deletion of instance: 111495 [Deleted:500268] Deletion of instance: 74231 [Deleted:500267] Deletion of instances: 74230, 74219 [Deleted:8959451] Deletion of instance: 73847
displayName	Purine ribonucleoside monophosphate biosynthesis
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-8956320] Nucleotide biosynthesis - Homo sapiens
figure	[Figure:77395] /figures/denovo_IMP_synthesis.jpg
goBiologicalProcess	[GO_BiologicalProcess:15969] purine ribonucleoside monophosphate biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-111285] Formation of phosphoribosyl pyrophosphate amidotransferase tetramer - Homo sapiens [Reaction:R-HSA-111289] Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer - Homo sapiens [Reaction:R-HSA-73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - Homo sapiens [Reaction:R-HSA-73814] 5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi - Homo sapiens [Reaction:R-HSA-73813] GAR + 10-Formyl-THF => FGAR + THF - Homo sapiens [Reaction:R-HSA-73812] FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi - Homo sapiens [Reaction:R-HSA-73810] FGAM + ATP => AIR + ADP + Pi - Homo sapiens [Reaction:R-HSA-73806] AIR + CO2 => CAIR - Homo sapiens [Reaction:R-HSA-73805] CAIR + Aspartate + ATP => SAICAR + ADP + Pi - Homo sapiens [Reaction:R-HSA-73800] SAICAR => AICAR + Fumarate - Homo sapiens [Reaction:R-HSA-73798] AICAR + 10-Formyl-THF => FAICAR + THF - Homo sapiens [Reaction:R-HSA-73797] FAICAR => IMP + H2O - Homo sapiens [Reaction:R-HSA-73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] - Homo sapiens [Reaction:R-HSA-9678749] IMPDH tetramers bind IMPDH inhibitors - Homo sapiens [Reaction:R-HSA-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-111524] IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] - Homo sapiens [Reaction:R-HSA-73828] adenylosuccinate => adenosine 5'-monophosphate + fumarate - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:111329] De novo purine nucleotide biosynthesis
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Purine ribonucleoside monophosphate biosynthesis
orthologousEvent	[Pathway:R-RNO-73817] Purine ribonucleoside monophosphate biosynthesis - Rattus norvegicus [Pathway:R-CFA-73817] Purine ribonucleoside monophosphate biosynthesis - Canis familiaris [Pathway:R-BTA-73817] Purine ribonucleoside monophosphate biosynthesis - Bos taurus [Pathway:R-SSC-73817] Purine ribonucleoside monophosphate biosynthesis - Sus scrofa [Pathway:R-DRE-73817] Purine ribonucleoside monophosphate biosynthesis - Danio rerio [Pathway:R-XTR-73817] Purine ribonucleoside monophosphate biosynthesis - Xenopus tropicalis [Pathway:R-GGA-73817] Purine ribonucleoside monophosphate biosynthesis - Gallus gallus [Pathway:R-DME-73817] Purine ribonucleoside monophosphate biosynthesis - Drosophila melanogaster [Pathway:R-CEL-73817] Purine ribonucleoside monophosphate biosynthesis - Caenorhabditis elegans [Pathway:R-DDI-73817] Purine ribonucleoside monophosphate biosynthesis - Dictyostelium discoideum [Pathway:R-SPO-73817] Purine ribonucleoside monophosphate biosynthesis - Schizosaccharomyces pombe [Pathway:R-SCE-73817] Purine ribonucleoside monophosphate biosynthesis - Saccharomyces cerevisiae [Pathway:R-PFA-73817] Purine ribonucleoside monophosphate biosynthesis - Plasmodium falciparum [Pathway:R-MMU-73817] Purine ribonucleoside monophosphate biosynthesis - Mus musculus
releaseDate	2004-07-06
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-73817
summation	[Summation:73818] The purine ribonucleotide inosine 5'-monophosphate (IMP) is ...
updateTrackers	[UpdateTracker:9784033] Update Tracker - [Pathway:73817] Purine ribonucleoside monophosphate biosynthesis - v55:[addHasEvent] [UpdateTracker:9776786] Update Tracker - [Pathway:73817] Purine ribonucleoside monophosphate biosynthesis - v74:[addHasEvent, updateContainedRLE] [UpdateTracker:9775960] Update Tracker - [Pathway:73817] Purine ribonucleoside monophosphate biosynthesis - v78:[removeHasEvent, updateContainedRLE] [UpdateTracker:9791047] Update Tracker - [Pathway:73817] Purine ribonucleoside monophosphate biosynthesis - v32:[addHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9791549] Update Tracker - [Pathway:73817] Purine ribonucleoside monophosphate biosynthesis - v29:[updateContainedRLE] [UpdateTracker:9790653] Update Tracker - [Pathway:73817] Purine ribonucleoside monophosphate biosynthesis - v33:[addHasEvent] [UpdateTracker:9786423] Update Tracker - [Pathway:73817] Purine ribonucleoside monophosphate biosynthesis - v49:[updateContainedRLE] [UpdateTracker:9790062] Update Tracker - [Pathway:73817] Purine ribonucleoside monophosphate biosynthesis - v35:[updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-8956320] Nucleotide biosynthesis
(replacementInstances)	[Deleted:500271] Deletion of instance: 74226 [Deleted:500269] Deletion of instance: 111585 [Deleted:500270] Deletion of instance: 111495 [Deleted:500268] Deletion of instance: 74231 [Deleted:500267] Deletion of instances: 74230, 74219 [Deleted:8959451] Deletion of instance: 73847
(updatedInstance)	[UpdateTracker:9784033] Update Tracker - [Pathway:73817] Purine ribonucleoside monophosphate biosynthesis - v55:[addHasEvent] [UpdateTracker:9776786] Update Tracker - [Pathway:73817] Purine ribonucleoside monophosphate biosynthesis - v74:[addHasEvent, updateContainedRLE] [UpdateTracker:9775960] Update Tracker - [Pathway:73817] Purine ribonucleoside monophosphate biosynthesis - v78:[removeHasEvent, updateContainedRLE] [UpdateTracker:9791047] Update Tracker - [Pathway:73817] Purine ribonucleoside monophosphate biosynthesis - v32:[addHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9791549] Update Tracker - [Pathway:73817] Purine ribonucleoside monophosphate biosynthesis - v29:[updateContainedRLE] [UpdateTracker:9790653] Update Tracker - [Pathway:73817] Purine ribonucleoside monophosphate biosynthesis - v33:[addHasEvent] [UpdateTracker:9786423] Update Tracker - [Pathway:73817] Purine ribonucleoside monophosphate biosynthesis - v49:[updateContainedRLE] [UpdateTracker:9790062] Update Tracker - [Pathway:73817] Purine ribonucleoside monophosphate biosynthesis - v35:[updateContainedRLE]

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