Reactome | Formation of the ternary complex, and subsequently, the 43S complex

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Formation of the ternary complex, and subsequently, the 43S complex Show undefined attributes

compartment	[Compartment:70101] cytosol
dbId	72695
displayName	Formation of the ternary complex, and subsequently, the 43S complex
eventOf	[Pathway:R-HSA-72737] Cap-dependent Translation Initiation - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-72663] De novo formation of eIF2:GTP - Homo sapiens [Reaction:R-HSA-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex - Homo sapiens [Reaction:R-HSA-72691] Formation of the 43S pre-initiation complex - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2011-09-30
literatureReference	[LiteratureReference:72677] Binding and release of radiolabeled eukaryotic initiation factors 2 and 3 during 80 S initiation complex formation [LiteratureReference:72665] Binding of MET-TRNAf and GTP to homogeneous initiation factor MP [LiteratureReference:72652] Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors [Book:72692] 9783642751394 New insights into an old problem: ternary complex (Met-tRNAf.eIF.GTP) formation in animal cells. Post-Transcriptional Control of Gene Expression McCarthy, John E G [LiteratureReference:72650] The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Formation of the ternary complex, and subsequently, the 43S complex
orthologousEvent	[Pathway:R-RNO-72695] Formation of the ternary complex, and subsequently, the 43S complex - Rattus norvegicus [Pathway:R-PFA-72695] Formation of the ternary complex, and subsequently, the 43S complex - Plasmodium falciparum [Pathway:R-SCE-72695] Formation of the ternary complex, and subsequently, the 43S complex - Saccharomyces cerevisiae [Pathway:R-SPO-72695] Formation of the ternary complex, and subsequently, the 43S complex - Schizosaccharomyces pombe [Pathway:R-DDI-72695] Formation of the ternary complex, and subsequently, the 43S complex - Dictyostelium discoideum [Pathway:R-CEL-72695] Formation of the ternary complex, and subsequently, the 43S complex - Caenorhabditis elegans [Pathway:R-DME-72695] Formation of the ternary complex, and subsequently, the 43S complex - Drosophila melanogaster [Pathway:R-GGA-72695] Formation of the ternary complex, and subsequently, the 43S complex - Gallus gallus [Pathway:R-XTR-72695] Formation of the ternary complex, and subsequently, the 43S complex - Xenopus tropicalis [Pathway:R-DRE-72695] Formation of the ternary complex, and subsequently, the 43S complex - Danio rerio [Pathway:R-SSC-72695] Formation of the ternary complex, and subsequently, the 43S complex - Sus scrofa [Pathway:R-BTA-72695] Formation of the ternary complex, and subsequently, the 43S complex - Bos taurus [Pathway:R-CFA-72695] Formation of the ternary complex, and subsequently, the 43S complex - Canis familiaris [Pathway:R-MMU-72695] Formation of the ternary complex, and subsequently, the 43S complex - Mus musculus
precedingEvent	[Pathway:R-HSA-72689] Formation of a pool of free 40S subunits - Homo sapiens [Reaction:R-HSA-72676] eIF3 and eIF1A bind to the 40S subunit - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-72695
summation	[Summation:72696] Binding of the methionyl-tRNA initiator to the active eIF2:G...
updateTrackers	[UpdateTracker:9789306] Update Tracker - [Pathway:72695] Formation of the ternary complex, and subsequently, the 43S complex - v38:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9789306] Update Tracker - [Pathway:72695] Formation of the ternary complex, and subsequently, the 43S complex - v38:[addLiteratureReference]
(hasEvent)	[Pathway:R-HSA-72737] Cap-dependent Translation Initiation

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