Reactome | Formation of the ternary complex, and subsequently, the 43S complex

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Formation of the ternary complex, and subsequently, the 43S complex Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10098615
displayName	Formation of the ternary complex, and subsequently, the 43S complex
eventOf	[Pathway:R-MMU-72737] Cap-dependent Translation Initiation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-72663] De novo formation of eIF2:GTP - Mus musculus [Reaction:R-MMU-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex - Mus musculus [Reaction:R-MMU-72691] Formation of the 43S pre-initiation complex - Mus musculus
inferredFrom	[Pathway:R-HSA-72695] Formation of the ternary complex, and subsequently, the 43S complex - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Formation of the ternary complex, and subsequently, the 43S complex
precedingEvent	[Pathway:R-MMU-72689] Formation of a pool of free 40S subunits - Mus musculus [Reaction:R-MMU-72676] eIF3 and eIF1A bind to the 40S subunit - Mus musculus
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-72695
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-72737] Cap-dependent Translation Initiation
(inferredTo)	[Pathway:R-HSA-72695] Formation of the ternary complex, and subsequently, the 43S complex

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