Reactome | De novo formation of eIF2:GTP

Schema > Reaction > Entries

De novo formation of eIF2:GTP Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
dbId	72663
displayName	De novo formation of eIF2:GTP
eventOf	[Pathway:R-HSA-72695] Formation of the ternary complex, and subsequently, the 43S complex - Homo sapiens
followingEvent	[Reaction:R-HSA-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex - Homo sapiens
input	[Complex:R-HSA-72515] EIF2S1:EIF2S2:EIF2S3 [cytosol] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isInDisease	false
isInferred	false
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	De novo formation of eIF2:GTP
orthologousEvent	[Reaction:R-RNO-72663] De novo formation of eIF2:GTP - Rattus norvegicus [Reaction:R-PFA-72663] De novo formation of eIF2:GTP - Plasmodium falciparum [Reaction:R-SCE-72663] De novo formation of eIF2:GTP - Saccharomyces cerevisiae [Reaction:R-SPO-72663] De novo formation of eIF2:GTP - Schizosaccharomyces pombe [Reaction:R-DDI-72663] De novo formation of eIF2:GTP - Dictyostelium discoideum [Reaction:R-CEL-72663] De novo formation of eIF2:GTP - Caenorhabditis elegans [Reaction:R-DME-72663] De novo formation of eIF2:GTP - Drosophila melanogaster [Reaction:R-GGA-72663] De novo formation of eIF2:GTP - Gallus gallus [Reaction:R-XTR-72663] De novo formation of eIF2:GTP - Xenopus tropicalis [Reaction:R-DRE-72663] De novo formation of eIF2:GTP - Danio rerio [Reaction:R-SSC-72663] De novo formation of eIF2:GTP - Sus scrofa [Reaction:R-BTA-72663] De novo formation of eIF2:GTP - Bos taurus [Reaction:R-CFA-72663] De novo formation of eIF2:GTP - Canis familiaris [Reaction:R-MMU-72663] De novo formation of eIF2:GTP - Mus musculus
output	[Complex:R-HSA-72531] eIF2:GTP [cytosol]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-72663
summation	[Summation:72664] Activation of eIF2 through direct binding of GTP. ...

Referrals

(hasEvent)	[Pathway:R-HSA-72695] Formation of the ternary complex, and subsequently, the 43S complex
(precedingEvent)	[Reaction:R-HSA-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex