Reactome | Met-tRNAi binds to eIF2:GTP to form the ternary complex

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Met-tRNAi binds to eIF2:GTP to form the ternary complex Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
dbId	72669
displayName	Met-tRNAi binds to eIF2:GTP to form the ternary complex
eventOf	[Pathway:R-HSA-72695] Formation of the ternary complex, and subsequently, the 43S complex - Homo sapiens
followingEvent	[Reaction:R-HSA-72691] Formation of the 43S pre-initiation complex - Homo sapiens
input	[Complex:R-HSA-72531] eIF2:GTP [cytosol] [OtherEntity:R-ALL-72393] Met-tRNAi [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:72665] Binding of MET-TRNAf and GTP to homogeneous initiation factor MP
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Met-tRNAi binds to eIF2:GTP to form the ternary complex
orthologousEvent	[Reaction:R-RNO-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex - Rattus norvegicus [Reaction:R-PFA-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex - Plasmodium falciparum [Reaction:R-SCE-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex - Saccharomyces cerevisiae [Reaction:R-SPO-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex - Schizosaccharomyces pombe [Reaction:R-DDI-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex - Dictyostelium discoideum [Reaction:R-CEL-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex - Caenorhabditis elegans [Reaction:R-DME-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex - Drosophila melanogaster [Reaction:R-GGA-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex - Gallus gallus [Reaction:R-XTR-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex - Xenopus tropicalis [Reaction:R-DRE-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex - Danio rerio [Reaction:R-SSC-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex - Sus scrofa [Reaction:R-BTA-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex - Bos taurus [Reaction:R-CFA-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex - Canis familiaris [Reaction:R-MMU-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex - Mus musculus
output	[Complex:R-HSA-72532] ternary complex [cytosol]
precedingEvent	[Reaction:R-HSA-379994] methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-72663] De novo formation of eIF2:GTP - Homo sapiens [Reaction:R-HSA-72722] eIF2 activation - Homo sapiens
regulatedBy	[Requirement:R-HSA-72779] Requirement by 'GTP [cytosol]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-72669
summation	[Summation:72742] The ternary complex forms upon binding of the initiator meth...

Referrals

(hasEvent)	[Pathway:R-HSA-72695] Formation of the ternary complex, and subsequently, the 43S complex
(precedingEvent)	[Reaction:R-HSA-72691] Formation of the 43S pre-initiation complex