Reactome | eIF2 activation

Schema > Reaction > Entries

eIF2 activation Show undefined attributes

catalystActivity	[CatalystActivity:72528] translation initiation factor activity of eIF2B subunits complex [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
dbId	72722
displayName	eIF2 activation
eventOf	[Pathway:R-HSA-72731] Recycling of eIF2:GDP - Homo sapiens
followingEvent	[Reaction:R-HSA-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex - Homo sapiens
input	[Complex:R-HSA-72529] eIF2:GDP: eIF2B [cytosol] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:72723] The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2 [LiteratureReference:72727] Mechanism of the nucleotide exchange reaction in eukaryotic polypeptide chain initiation. Characterization of the guanine nucleotide exchange factor as a GTP-binding protein
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	eIF2 activation
orthologousEvent	[Reaction:R-RNO-72722] eIF2 activation - Rattus norvegicus [Reaction:R-PFA-72722] eIF2 activation - Plasmodium falciparum [Reaction:R-SCE-72722] eIF2 activation - Saccharomyces cerevisiae [Reaction:R-SPO-72722] eIF2 activation - Schizosaccharomyces pombe [Reaction:R-DDI-72722] eIF2 activation - Dictyostelium discoideum [Reaction:R-CEL-72722] eIF2 activation - Caenorhabditis elegans [Reaction:R-DME-72722] eIF2 activation - Drosophila melanogaster [Reaction:R-GGA-72722] eIF2 activation - Gallus gallus [Reaction:R-DRE-72722] eIF2 activation - Danio rerio [Reaction:R-SSC-72722] eIF2 activation - Sus scrofa [Reaction:R-BTA-72722] eIF2 activation - Bos taurus [Reaction:R-CFA-72722] eIF2 activation - Canis familiaris [Reaction:R-MMU-72722] eIF2 activation - Mus musculus
output	[Complex:R-HSA-72531] eIF2:GTP [cytosol] [Complex:R-HSA-72526] eIF2B subunits complex [cytosol] [SimpleEntity:R-ALL-29420] GDP [cytosol]
precedingEvent	[Reaction:R-HSA-72670] Formation of eIF2:GDP:eIF2B intermediate - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-72722
summation	[Summation:72730] eIF2B is a guanine nucleotide releasing factor that is requi...

Referrals

(hasEvent)	[Pathway:R-HSA-72731] Recycling of eIF2:GDP
(precedingEvent)	[Reaction:R-HSA-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex