Reactome | AFMID hydrolyses NFK to L-KYN

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AFMID hydrolyses NFK to L-KYN Show undefined attributes

authored	[InstanceEdit:164915] D'Eustachio, P, 2005-07-20 13:46:37
catalystActivity	[CatalystActivity:178109] arylformamidase activity of AFMID [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:12667988] RHEA:13010 [DatabaseIdentifier:9929638] RHEA:13010
dbId	71189
displayName	AFMID hydrolyses NFK to L-KYN
edited	[InstanceEdit:164915] D'Eustachio, P, 2005-07-20 13:46:37
eventOf	[Pathway:R-HSA-71240] Tryptophan catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-9971629] Unknown NAT N-acetylates kynurenine - Homo sapiens [Reaction:R-HSA-901097] PXLP-KYAT3 (CCBL2) dimer transaminates L-KYN to KYNA - Homo sapiens [Reaction:R-HSA-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Homo sapiens [Reaction:R-HSA-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Homo sapiens
inferredFrom	[Reaction:R-MMU-71196] N-formylkynurenine + H2O => kynurenine + formate [mouse] - Mus musculus
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-33179] NFK [cytosol]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:71192] Kynurenine formamidase: determination of primary structure and modeling-based prediction of tertiary structure and catalytic triad
maxDepth	1
modified	[InstanceEdit:9939374] D'Eustachio, Peter, 2025-02-25
name	AFMID hydrolyses NFK to L-KYN H2O + N-formyl-L-kynurenine => formate + H(+) + L-kynurenine N-formylkynurenine + H2O => kynurenine + formate
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29460] HCOOH [cytosol] [SimpleEntity:R-ALL-29970] L-KYN [cytosol]
precedingEvent	[Reaction:R-HSA-71188] TDO tetramer dioxygenates L-Trp to NFK - Homo sapiens [Reaction:R-HSA-198563] IDO1 dioxygenates L-Trp to NFK - Homo sapiens [Reaction:R-HSA-888614] IDO2 dioxygenates L-Trp to NFK - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9939375] Hill, David P, 2025-02-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-71189
summation	[Summation:178964] Cytosolic arylformamidase (AFMID) catalyzes the hydrolysis o...
updateTrackers	[UpdateTracker:9788551] Update Tracker - [Reaction:71189] AFMID hydrolyses NFK to L-KYN - v41:[addLiteratureReference, modifyText] [UpdateTracker:9939773] Update Tracker - [Reaction:71189] AFMID hydrolyses NFK to L-KYN - v92:[removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9788551] Update Tracker - [Reaction:71189] AFMID hydrolyses NFK to L-KYN - v41:[addLiteratureReference, modifyText] [UpdateTracker:9939773] Update Tracker - [Reaction:71189] AFMID hydrolyses NFK to L-KYN - v92:[removeOutput]
(precedingEvent)	[Reaction:R-HSA-9971629] Unknown NAT N-acetylates kynurenine [Reaction:R-HSA-901097] PXLP-KYAT3 (CCBL2) dimer transaminates L-KYN to KYNA [Reaction:R-HSA-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA [Reaction:R-HSA-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O
(hasEvent)	[Pathway:R-HSA-71240] Tryptophan catabolism
(inferredTo)	[Reaction:R-MMU-71196] N-formylkynurenine + H2O => kynurenine + formate [mouse]

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